Nub1 MGI Mouse Gene Detail - MGI:1889001 - negative regulator of ubiquitin-like proteins 1

Symbol

Nub1
Name

negative regulator of ubiquitin-like proteins 1
Synonyms

4931404D21Rik, 6330412F12Rik, BS4, NY-REN-18

Feature Type

protein coding gene
IDs

MGI:1889001
NCBI Gene: 53312
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:24890813-24915376 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 11.93 cM
Mapping Data

1 experiment

SNPs within 2kb

290 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889001	protein coding gene	Chr5:24890530-24915376 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029353	protein coding gene	Chr5:22447755-22473331 (+)
A/J	MGP_AJ_G0029319	protein coding gene	Chr5:21661336-21690647 (+)
AKR/J	MGP_AKRJ_G0029270	protein coding gene	Chr5:22539682-22564611 (+)
BALB/cJ	MGP_BALBcJ_G0029330	protein coding gene	Chr5:22176882-22201726 (+)
C3H/HeJ	MGP_C3HHeJ_G0029050	protein coding gene	Chr5:22651181-22676100 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029783	protein coding gene	Chr5:23941878-23968176 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027021	protein coding gene	Chr5:19597926-19622072 (+)
CAST/EiJ	MGP_CASTEiJ_G0028462	protein coding gene	Chr5:21840655-21867617 (+)
CBA/J	MGP_CBAJ_G0029017	protein coding gene	Chr5:24345075-24372394 (+)
DBA/2J	MGP_DBA2J_G0029168	protein coding gene	Chr5:21955352-21978604 (+)
FVB/NJ	MGP_FVBNJ_G0029126	protein coding gene	Chr5:21332066-21356908 (+)
LP/J	MGP_LPJ_G0029252	protein coding gene	Chr5:22843269-22867987 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029155	protein coding gene	Chr5:25442229-25469335 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029817	protein coding gene	Chr5:22188367-22213217 (+)
PWK/PhJ	MGP_PWKPhJ_G0028186	protein coding gene	Chr5:21050102-21073769 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028017	protein coding gene	Chr5:21534316-21562452 (+)
WSB/EiJ	MGP_WSBEiJ_G0028542	protein coding gene	Chr5:22261078-22286853 (+)

Human Ortholog

NUB1, negative regulator of ubiquitin like proteins 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUB1, negative regulator of ubiquitin like proteins 1
Synonyms

BS4, NUB1L, NYREN18
Links

HGNC:17623

NCBI Gene ID: 51667

neXtProt AC: NX_Q9Y5A7

UniProt: Q9Y5A7
Chr Location

7q36.1; chr7:151341699-151378461 (+) GRCh38.p7

Alliance of Genome Resources

Nub1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUB1
Gene Tree

Nub1

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References

1 with disease annotations

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Phenotype Summary

25 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Gene trapped

9
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Nub1
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

71
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nub1

ZFIN nub1

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Nub1 interacts with 171 markers (Mir1a-1, Mir1a-2, Mir17, ...) View All

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All Sequences

57
RefSeq

4
UniProt

5
CCDS

CCDS39030.1, CCDS80230.1

Ensembl

ENSMUSG00000028954 (Evidence)
NCBI Gene

53312

			Length	Strain/Species	Flank
genomic	53312	NCBI Gene Model \| MGI Sequence Detail	24564	C57BL/6J	± kb
transcript	NM_016736	RefSeq \| MGI Sequence Detail	3293	C57BL/6
polypeptide	P54729	UniProt \| EBI \| MGI Sequence Detail	614	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011475 NEDD8 ultimate buster 1

(term hierarchy)
PDB

1VEG
InterPro Domains

IPR039749 NEDD8 ultimate buster 1

IPR041207 NEDD8 ultimate buster 1, ubiquitin-like domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:1921250, MGI:1926009

Summaries

All 43

Developmental Gene Expression 4

Diseases 1

Gene Ontology 3

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:233339 Tanji K, et al., The role of NUB1 in alpha-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016 Feb 12;470(3):635-42

TSS for Nub1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45443	Chr5:24890813-24890817 (+)	2 bp
Tssr45444	Chr5:24890831-24890851 (+)	28 bp
Tssr45445	Chr5:24890952-24891002 (+)	164 bp
Tssr45446	Chr5:24902074-24902092 (+)	11,270 bp
Tssr45447	Chr5:24914060-24914077 (+)	23,256 bp
Tssr45448	Chr5:24914565-24914589 (+)	23,764 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 05/24/2023 MGI 6.22