Zfp276 MGI Mouse Gene Detail - MGI:1888495 - zinc finger protein (C2H2 type) 276

Symbol

Zfp276
Name

zinc finger protein (C2H2 type) 276
Synonyms

D8Ertd370e, D8Ertd377e

Feature Type

protein coding gene
IDs

MGI:1888495
NCBI Gene: 57247
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:123980934-123996484 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.09 cM
Mapping Data

5 experiments

SNPs within 2kb

107 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888495	protein coding gene	Chr8:123980934-123997290 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034250	protein coding gene	Chr8:126857370-126872947 (+)
A/J	MGP_AJ_G0034230	protein coding gene	Chr8:121602372-121618997 (+)
AKR/J	MGP_AKRJ_G0034157	protein coding gene	Chr8:125131225-125149234 (+)
BALB/cJ	MGP_BALBcJ_G0034223	protein coding gene	Chr8:121810689-121826320 (+)
C3H/HeJ	MGP_C3HHeJ_G0033934	protein coding gene	Chr8:125834947-125851301 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034743	protein coding gene	Chr8:131103034-131119532 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031685	protein coding gene	Chr8:114420621-114435926 (+)
CAST/EiJ	MGP_CASTEiJ_G0033262	protein coding gene	Chr8:125915257-125946735 (+)
CBA/J	MGP_CBAJ_G0033907	protein coding gene	Chr8:135918156-135933485 (+)
DBA/2J	MGP_DBA2J_G0034063	protein coding gene	Chr8:120780026-120795837 (+)
FVB/NJ	MGP_FVBNJ_G0034007	protein coding gene	Chr8:119946420-119961907 (+)
LP/J	MGP_LPJ_G0034153	protein coding gene	Chr8:126988448-127006893 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034054	protein coding gene	Chr8:138052257-138075685 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034762	protein coding gene	Chr8:125348303-125364046 (+)
PWK/PhJ	MGP_PWKPhJ_G0032963	protein coding gene	Chr8:120610500-120626720 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032803	protein coding gene	Chr8:124065083-124080152 (+)
WSB/EiJ	MGP_WSBEiJ_G0033378	protein coding gene	Chr8:126084728-126100905 (+)

Human Ortholog

ZNF276, zinc finger protein 276

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF276, zinc finger protein 276
Synonyms

CENPZ, CENP-Z, ZADT, ZFP276, ZNF477
Links

HGNC:23330

NCBI Gene ID: 92822

neXtProt AC: NX_Q8N554

UniProt: Q8N554
Chr Location

16q24.3; chr16:89720368-89740925 (+) GRCh38

MGI Vertebrate Homology

Zfp276 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF276
Gene Tree

Zfp276

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

less

All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

73
cDNA Data

17
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase znf276

less

All Sequences

73
RefSeq

15
UniProt

3
CCDS

CCDS52699.1

Ensembl

ENSMUSG00000001065 (Evidence)
NCBI Gene

57247

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001065	Ensembl Gene Model \| MGI Sequence Detail	15551	C57BL/6J	± kb
transcript	ENSMUST00000001092	Ensembl \| MGI Sequence Detail	4071	Not Applicable
polypeptide	ENSMUSP00000001092	Ensembl \| MGI Sequence Detail	614	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000017797 zinc finger protein 276

(term hierarchy)
InterPro Domains

IPR012934 Zinc finger, AD-type

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

less

All nucleic 24

Genomic 1

cDNA 19

Primer pair 4

Microarray probesets 6

less

MGI:1196248, MGI:1196409, MGI:2142748

Summaries

All 34

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 3
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:324574 Aberle T, et al., Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Nucleic Acids Res. 2022 Feb 28;50(4):1951-1968

TSS for Zfp276:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79936	Chr8:123980970-123981017 (+)	60 bp
Tssr79937	Chr8:123981031-123981056 (+)	110 bp
Tssr2724	Chr8:123981058-123981069 (+)	130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23