Pcnx3 MGI Mouse Gene Detail - MGI:1861733

Symbol

Pcnx3
Name

pecanex homolog 3
Synonyms

Pcnxl3

Feature Type

protein coding gene
IDs

MGI:1861733
NCBI Gene: 104401
Alliance

gene page
Transcription Start Sites

2 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr19:5714663-5738936 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM
Mapping Data

2 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861733	protein coding gene	Chr19:5714663-5739036 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024721	protein coding gene	Chr19:2649757-2673317 (-)
A/J	MGP_AJ_G0024687	protein coding gene	Chr19:2504186-2528034 (-)
AKR/J	MGP_AKRJ_G0024660	protein coding gene	Chr19:2570625-2594473 (-)
BALB/cJ	MGP_BALBcJ_G0024687	protein coding gene	Chr19:2498527-2522429 (-)
C3H/HeJ	MGP_C3HHeJ_G0024455	protein coding gene	Chr19:2588818-2612720 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025134	protein coding gene	Chr19:2717409-2740961 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022564	protein coding gene	Chr19:2413153-2436769 (-)
CAST/EiJ	MGP_CASTEiJ_G0023927	protein coding gene	Chr19:2606000-2632105 (-)
CBA/J	MGP_CBAJ_G0024427	protein coding gene	Chr19:2839581-2866448 (-)
DBA/2J	MGP_DBA2J_G0024554	protein coding gene	Chr19:2500422-2523971 (-)
FVB/NJ	MGP_FVBNJ_G0024520	protein coding gene	Chr19:2496756-2521193 (-)
LP/J	MGP_LPJ_G0024640	protein coding gene	Chr19:2625114-2649275 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024550	protein coding gene	Chr19:2684734-2711014 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025182	protein coding gene	Chr19:2591157-2614709 (-)
PWK/PhJ	MGP_PWKPhJ_G0023673	protein coding gene	Chr19:2522469-2546494 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023478	protein coding gene	Chr19:2574296-2598994 (-)
WSB/EiJ	MGP_WSBEiJ_G0023989	protein coding gene	Chr19:2600972-2624555 (-)

Human Ortholog

PCNX3, pecanex 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCNX3, pecanex 3
Synonyms

PCNXL3
Links

HGNC:18760

NCBI Gene ID: 399909

neXtProt AC: NX_Q9H6A9

UniProt: Q9H6A9
Chr Location

11q13.1; chr11:65615776-65637439 (+) GRCh38

MGI Vertebrate Homology

Pcnx3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PCNX3
Gene Tree

Pcnx3

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

6
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

53
cDNA Data

112
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

80
RefSeq

22
UniProt

8
CCDS

CCDS29475.2

Ensembl

ENSMUSG00000054874 (Evidence)
NCBI Gene

104401

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054874	Ensembl Gene Model \| MGI Sequence Detail	24274	C57BL/6J	± kb
transcript	ENSMUST00000113615	Ensembl \| MGI Sequence Detail	7264	Not Applicable
polypeptide	ENSMUSP00000109245	Ensembl \| MGI Sequence Detail	2028	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012426 pecanex-like protein 3

(term hierarchy)
InterPro Domains

IPR007735 Pecanex, C-terminal

IPR039797 Protein Pecanex

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All nucleic 117

Genomic 4

cDNA 113

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 8
Earliest

J:63233 Saridaki A, et al., Genomic sequencing reveals the structure of the Kcnk6 and map3k11 genes and their close vicinity to the sipa1 gene on mouse chromosome 19. Cytogenet Cell Genet. 2000;89(1-2):85-8
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Pcnx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157627	Chr19:5738642-5738734 (-)	248 bp
Tssr157626	Chr19:5738568-5738618 (-)	343 bp

Pcnx3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Mtes1	Chr19, syntenic		J:103849	The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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