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Gnasas1 Gene Detail
Summary
  • Symbol
    Gnasas1
  • Name
    GNAS antisense RNA 1
  • Synonyms
    Gnas-as, Nespas
Location &
Maps
more
  • Sequence Map
    Chr2:174123030-174137229 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 97.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861674
 antisense lncRNA gene Chr2:174123024-174137229 (-)
129S1/SvImJ MGP_129S1SvImJ_G0003713
 antisense lncRNA gene Chr2:180627284-180641326 (-)
A/J MGP_AJ_G0003694
 antisense lncRNA gene Chr2:173016163-173030220 (-)
AKR/J MGP_AKRJ_G0003672
 antisense lncRNA gene Chr2:178231595-178245711 (-)
BALB/cJ MGP_BALBcJ_G0003683
 antisense lncRNA gene Chr2:173406808-173420921 (-)
C3H/HeJ MGP_C3HHeJ_G0003630
 antisense lncRNA gene Chr2:178608959-178623697 (-)
C57BL/6NJ MGP_C57BL6NJ_G0003822
 antisense lncRNA gene Chr2:185824524-185842593 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0003328
 antisense lncRNA gene Chr2:166257775-166272225 (-)
CAST/EiJ MGP_CASTEiJ_G0003593
 antisense lncRNA gene Chr2:179336280-179350803 (-)
CBA/J MGP_CBAJ_G0003627
 antisense lncRNA gene Chr2:192743640-192757770 (-)
DBA/2J MGP_DBA2J_G0003634
 antisense lncRNA gene Chr2:172116374-172130181 (-)
FVB/NJ MGP_FVBNJ_G0003656
 antisense lncRNA gene Chr2:170739323-170753354 (-)
LP/J MGP_LPJ_G0003713
 antisense lncRNA gene Chr2:180537667-180551840 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0003644
 antisense lncRNA gene Chr2:195641711-195656662 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0003823
 antisense lncRNA gene Chr2:178254953-178269893 (-)
PWK/PhJ MGP_PWKPhJ_G0003548
 antisense lncRNA gene Chr2:171923988-171938523 (-)
SPRET/EiJ MGP_SPRETEiJ_G0003491
 antisense lncRNA gene Chr2:177297465-177311616 (-)
WSB/EiJ MGP_WSBEiJ_G0003628
 antisense lncRNA gene Chr2:179218551-179234729 (-)



Homology
more
  • Human Ortholog
    GNAS-AS1, GNAS antisense RNA 1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAS-AS1, GNAS antisense RNA 1
  • Synonyms
    GNAS1AS, GNASAS, GNAS-AS, NCRNA00075, NESPAS, NESP-AS, SANG
  • Links
    NCBI Gene ID: 149775

  • Chr Location
    20q13.32; chr20:58818918-58850903 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gnasas1 mouse models; 1 with human GNAS-AS1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit postnatal lethality, abnormal suckling, lethargy, decreased body size, and altered maternal imprinting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    11
  • cDNA Data
    2
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      31
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56802 NCBI Gene Model | MGI Sequence Detail 14200 C57BL/6J ±  kb
    transcript NR_002846 RefSeq | MGI Sequence Detail 2248 ZRU/MplStud  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 3
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:61327 Wroe SF, et al., An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3342-6
    • Latest
      J:302583 Jiang W, et al., ZFP57 dictates allelic expression switch of target imprinted genes. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2005377118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/09/2024
    MGI 6.23     		The Jackson Laboratory