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Rdh7 Gene Detail
Summary
  • Symbol
    Rdh7
  • Name
    retinol dehydrogenase 7
  • Synonyms
    CRAD2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860517
    NCBI Gene: 54150
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:127719897-127724686 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.39 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860517
 protein coding gene Chr10:127719896-127725116 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017841
 protein coding gene Chr10:131536043-131540632 (-)
A/J MGP_AJ_G0017816
 protein coding gene Chr10:126282904-126287578 (-)
AKR/J MGP_AKRJ_G0017779
 protein coding gene Chr10:129993074-130000025 (-)
BALB/cJ MGP_BALBcJ_G0017780
 protein coding gene Chr10:126666222-126670961 (-)
C3H/HeJ MGP_C3HHeJ_G0017604
 protein coding gene Chr10:130134395-130138952 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018235
 protein coding gene Chr10:135986174-135990846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015913
 protein coding gene Chr10:120243406-120249352 (-)
CAST/EiJ MGP_CASTEiJ_G0017164
 protein coding gene Chr10:130839918-130846041 (-)
CBA/J MGP_CBAJ_G0017573
 protein coding gene Chr10:141520426-141529931 (-)
DBA/2J MGP_DBA2J_G0017679
 protein coding gene Chr10:125357228-125361864 (-)
FVB/NJ MGP_FVBNJ_G0017674
 protein coding gene Chr10:124293546-124298810 (-)
LP/J MGP_LPJ_G0017753
 protein coding gene Chr10:132150938-132158914 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017702
 protein coding gene Chr10:144138436-144143930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018275
 protein coding gene Chr10:130086730-130094686 (-)
PWK/PhJ MGP_PWKPhJ_G0016949
 protein coding gene Chr10:125582829-125589465 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0017223
 protein coding gene Chr10:130308865-130314276 (-)



Homology
more
  • Human Ortholog
    RDH16, retinol dehydrogenase 16
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDH16, retinol dehydrogenase 16
  • Synonyms
    hRDH-E, RODH4, RODH-4, SDR9C8
  • Links
    NCBI Gene ID: 8608
    neXtProt AC: NX_O75452
    UniProt: O75452

  • Chr Location
    12q13.3; chr12:56951431-56959374 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mcie homozygous for a conditional allele activated in enterocytes exhibit reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells and enhanced resistance to colonization by gut pathogens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    25
  • cDNA Data
    98
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040134 Ensembl Gene Model | MGI Sequence Detail 4790 C57BL/6J ±  kb
transcript ENSMUST00000047199 Ensembl | MGI Sequence Detail 1678 Not Applicable  
polypeptide ENSMUSP00000039252 Ensembl | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 102
    Genomic 1
    cDNA 98
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143533
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:48724 Su J, et al., cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. J Biol Chem. 1998 Jul 10;273(28):17910-6
  • Latest
    J:279231 Grizotte-Lake M, et al., Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis. Immunity. 2018 Dec 18;49(6):1103-1115.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory