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Prpf40a Gene Detail
Summary
  • Symbol
    Prpf40a
  • Name
    pre-mRNA processing factor 40A
  • Synonyms
    2810012K09Rik, FBP11, Fnbp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860512
    NCBI Gene: 56194
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:53024714-53081450 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 30.69 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1219 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860512
 protein coding gene Chr2:53024714-53081714 (-)
129S1/SvImJ ENSMUSG00200010619
 protein coding gene Chr2:50022423-50078807 (-)
A/J ENSMUSG00195009759
 protein coding gene Chr2:50170491-50226875 (-)
AKR/J ENSMUSG00220020621
 protein coding gene Chr2:50294939-50351325 (-)
BALB/cJ ENSMUSG00180020444
 protein coding gene Chr2:50153803-50210390 (-)
C3H/HeJ ENSMUSG00175013095
 protein coding gene Chr2:50194600-50250990 (-)
C57BL/6NJ ENSMUSG00215009357
 protein coding gene Chr2:50196435-50253017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023561
 protein coding gene Chr2:48451286-48506697 (-)
CAST/EiJ ENSTCUG00005001331
 protein coding gene Chr2:49696149-49752557 (-)
CBA/J ENSMUSG00210000849
 protein coding gene Chr2:50207677-50264063 (-)
DBA/2J ENSMUSG00185002554
 protein coding gene Chr2:50075172-50131566 (-)
FVB/NJ ENSMUSG00205001760
 protein coding gene Chr2:49871884-49928270 (-)
JF1/MsJ ENSUMUG00000000455
 protein coding gene Chr2:49899467-49955813 (-)
LP/J ENSMUSG00230001672
 protein coding gene Chr2:51974950-52031536 (-)
NOD/ShiLtJ ENSMUSG00190001926
 protein coding gene Chr2:50122693-50179089 (-)
NZO/HlLtJ ENSMUSG00225000382
 protein coding gene Chr2:59686086-59742667 (-)
PWK/PhJ ENSLUMG00010004105
 protein coding gene Chr2:50042963-50099522 (-)
SPRET/EiJ ENSMSPG00010011771
 protein coding gene Chr2:51046200-51100743 (-)
WSB/EiJ ENSIUOG00005001218
 protein coding gene Chr2:50147224-50200751 (-)



Homology
more
  • Human Ortholog
    PRPF40A, pre-mRNA processing factor 40A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPF40A, pre-mRNA processing factor 40A
  • Synonyms
    FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40
  • Links
    NCBI Gene ID: 55660
    UniProt: O75400

  • Chr Location
    2q23.3; chr2:152651593-152718048 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    124
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56194 NCBI Gene Model | MGI Sequence Detail 56737 C57BL/6J ±  kb
    transcript NM_001371015 RefSeq | MGI Sequence Detail 7417 C57BL/6  
    polypeptide Q9R1C7 UniProt | EBI | MGI Sequence Detail 953 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1922669
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory