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Abcb10 Gene Detail
Summary
  • Symbol
    Abcb10
  • Name
    ATP-binding cassette, sub-family B member 10
  • Synonyms
    ABC-me
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860508
    NCBI Gene: 56199
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124679198-124709861 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1043 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860508
protein coding gene Chr8:124679198-124709877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034266
protein coding gene Chr8:127593694-127628267 (-)
A/J MGP_AJ_G0034246
protein coding gene Chr8:122336553-122366930 (-)
AKR/J MGP_AKRJ_G0034173
protein coding gene Chr8:125852911-125885597 (-)
BALB/cJ MGP_BALBcJ_G0034239
protein coding gene Chr8:122521632-122551693 (-)
C3H/HeJ MGP_C3HHeJ_G0033950
protein coding gene Chr8:126486798-126518230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034759
protein coding gene Chr8:131879116-131915174 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031700
protein coding gene Chr8:115113125-115143324 (-)
CAST/EiJ MGP_CASTEiJ_G0033277
protein coding gene Chr8:126599964-126635281 (-)
CBA/J MGP_CBAJ_G0033923
protein coding gene Chr8:136699672-136737043 (-)
DBA/2J MGP_DBA2J_G0034079
protein coding gene Chr8:121489037-121519405 (-)
FVB/NJ MGP_FVBNJ_G0034023
protein coding gene Chr8:120652383-120683873 (-)
LP/J MGP_LPJ_G0034168
protein coding gene Chr8:127759345-127790747 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034070
protein coding gene Chr8:138826310-138864558 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034778
protein coding gene Chr8:126084569-126114651 (-)
PWK/PhJ MGP_PWKPhJ_G0032979
protein coding gene Chr8:121245803-121276530 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032818
protein coding gene Chr8:124726635-124760826 (-)
WSB/EiJ MGP_WSBEiJ_G0033394
protein coding gene Chr8:126811471-126844637 (-)



Homology
more
  • Human Ortholog
    ABCB10, ATP binding cassette subfamily B member 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCB10, ATP binding cassette subfamily B member 10
  • Synonyms
    EST20237, M-ABC2, MTABC2
  • Links
    NCBI Gene ID: 23456
    neXtProt AC: NX_Q9NRK6
    UniProt: Q9NRK6

  • Chr Location
    1q42.13; chr1:229516582-229558707 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased response to ischemia and reperfusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031974 Ensembl Gene Model | MGI Sequence Detail 30664 C57BL/6J ±  kb
    transcript ENSMUST00000075578 Ensembl | MGI Sequence Detail 4306 Not Applicable  
    polypeptide ENSMUSP00000075011 Ensembl | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003548 ATP-binding cassette sub-family B member 10, mitochondrial
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR039421 Type 1 protein exporter
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 84
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142681, MGI:2142839
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 17
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:347616 Do Y, et al., Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis. Biosci Rep. 2024 Apr 24;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/29/2024
    MGI 6.24
    The Jackson Laboratory