Tdp2 MGI Mouse Gene Detail - MGI:1860486 - tyrosyl-DNA phosphodiesterase 2

Symbol

Tdp2
Name

tyrosyl-DNA phosphodiesterase 2
Synonyms

D13Ertd656e, Ttrap

Feature Type

protein coding gene
IDs

MGI:1860486
NCBI Gene: 56196
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:25015662-25026136 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 10.70 cM
Mapping Data

2 experiments

SNPs within 2kb

141 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860486	protein coding gene	Chr13:25015642-25026136 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020382	protein coding gene	Chr13:22322221-22341339 (+)
A/J	MGP_AJ_G0020331	protein coding gene	Chr13:21917316-21927994 (+)
AKR/J	MGP_AKRJ_G0020311	protein coding gene	Chr13:22157307-22169269 (+)
BALB/cJ	MGP_BALBcJ_G0020329	protein coding gene	Chr13:21893557-21904865 (+)
C3H/HeJ	MGP_C3HHeJ_G0020133	protein coding gene	Chr13:22238887-22250831 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020766	protein coding gene	Chr13:23123183-23135834 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018354	protein coding gene	Chr13:20631018-20640214 (+)
CAST/EiJ	MGP_CASTEiJ_G0019650	protein coding gene	Chr13:21944859-21957803 (+)
CBA/J	MGP_CBAJ_G0020087	protein coding gene	Chr13:24010020-24022226 (+)
DBA/2J	MGP_DBA2J_G0020213	protein coding gene	Chr13:21411469-21423233 (+)
FVB/NJ	MGP_FVBNJ_G0020197	protein coding gene	Chr13:21058020-21070372 (+)
LP/J	MGP_LPJ_G0020286	protein coding gene	Chr13:22628149-22640596 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020224	protein coding gene	Chr13:24263812-24276845 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020808	protein coding gene	Chr13:22003360-22013880 (+)
PWK/PhJ	MGP_PWKPhJ_G0019404	protein coding gene	Chr13:21434790-21445873 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019220	protein coding gene	Chr13:20828909-20842916 (+)
WSB/EiJ	MGP_WSBEiJ_G0019710	protein coding gene	Chr13:22171571-22183586 (+)

Human Ortholog

TDP2, tyrosyl-DNA phosphodiesterase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDP2, tyrosyl-DNA phosphodiesterase 2
Synonyms

AD022, dJ30M3.3, EAP2, EAPII, hTDP2, TTRAP
Links

HGNC:17768

NCBI Gene ID: 51567

neXtProt AC: NX_O95551

UniProt: O95551
Chr Location

6p22.3; chr6:24649979-24666930 (-) GRCh38

MGI Vertebrate Homology

Tdp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDP2
Gene Tree

Tdp2

Diseases

1 with human TDP2 associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 23 IDs autosomal recessive spinocerebellar ataxia 23 DOID:0111613 OMIM:616949 ORDO:404493

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 1 genetic background
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Tdp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice carrying a gene trap insertion into intron 5 but subsequently shown to harbor a partial duplication of the wild-type allele at the ES cell level are born with a normal Mendelian distribution.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

30
cDNA Data

68
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdp2

ZFIN tdp2b

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All Sequences

55
RefSeq

2
UniProt

3
CCDS

CCDS26381.1

Ensembl

ENSMUSG00000035958 (Evidence)
NCBI Gene

56196

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035958	Ensembl Gene Model \| MGI Sequence Detail	10475	C57BL/6J	± kb
transcript	ENSMUST00000038039	Ensembl \| MGI Sequence Detail	1957	Not Applicable
polypeptide	ENSMUSP00000035660	Ensembl \| MGI Sequence Detail	370	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016802 tyrosyl-DNA phosphodiesterase 2

(term hierarchy)
PDB

4GYZ, 4GZ0, 4GZ1, 4GZ2, 4PUQ, 5HT2, 5INK, 5INL, 5INM, 5INN, 5INP, 5INQ, 5J3Z, 5J42, 5TVP, 5TVQ
EC

3.1.4.-
InterPro Domains

IPR005135 Endonuclease/exonuclease/phosphatase

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

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All nucleic 72

Genomic 1

cDNA 68

Primer pair 2

Other 1

Microarray probesets 3

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MGI:1289161

Summaries

All 52

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 19
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:287399 Alvarez-Quilon A, et al., Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency. Nat Commun. 2020 Feb 14;11(1):910

TSS for Tdp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118970	Chr13:25015644-25015670 (+)	-5 bp
Tssr118971	Chr13:25015683-25015704 (+)	32 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23