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Pck2 Gene Detail
Summary
  • Symbol
    Pck2
  • Name
    phosphoenolpyruvate carboxykinase 2 (mitochondrial)
  • Synonyms
    1810010O14Rik, 9130022B02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860456
    NCBI Gene: 74551
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55777721-55787477 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    279 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860456
 protein coding gene Chr14:55777721-55788699 (+)
129S1/SvImJ ENSMUSG00200041618
 protein coding gene Chr14:44365212-44376188 (+)
A/J ENSMUSG00195031470
 protein coding gene Chr14:44582105-44593099 (+)
AKR/J ENSMUSG00220024036
 protein coding gene Chr14:43910014-43920999 (+)
BALB/cJ ENSMUSG00180046412
 protein coding gene Chr14:44205846-44216822 (+)
C3H/HeJ ENSMUSG00175036712
 protein coding gene Chr14:45888196-45899176 (+)
C57BL/6NJ ENSMUSG00215046136
 protein coding gene Chr14:44100923-44111900 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019295
 protein coding gene Chr14:46962298-46971863 (+)
CAST/EiJ ENSTCUG00005045094
 protein coding gene Chr14:45883152-45894081 (+)
CBA/J ENSMUSG00210037276
 protein coding gene Chr14:44568639-44579621 (+)
DBA/2J ENSMUSG00185053342
 protein coding gene Chr14:49636073-49647045 (+)
FVB/NJ ENSMUSG00205031442
 protein coding gene Chr14:43979222-43990153 (+)
JF1/MsJ ENSUMUG00000020139
 protein coding gene Chr14:60867466-60878541 (+)
LP/J ENSMUSG00230052505
 protein coding gene Chr14:61731066-61742042 (+)
NOD/ShiLtJ ENSMUSG00190041799
 protein coding gene Chr14:44342605-44353536 (+)
NZO/HlLtJ ENSMUSG00225044234
 protein coding gene Chr14:52021655-52032631 (+)
PWK/PhJ ENSLUMG00010044103
 protein coding gene Chr14:43791384-43802360 (+)
SPRET/EiJ ENSMSPG00010044261
 protein coding gene Chr14:47197642-47207302 (+)
WSB/EiJ ENSIUOG00005037687
 protein coding gene Chr14:43783388-43794294 (+)



Homology
more
  • Human Ortholog
    PCK2, phosphoenolpyruvate carboxykinase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCK2, phosphoenolpyruvate carboxykinase 2, mitochondrial
  • Synonyms
    mtPCK2, PEPCK, PEPCK2, PEPCK-M
  • Links
    NCBI Gene ID: 5106
    UniProt: Q16822

  • Chr Location
    14q11.2-q12; chr14:24094053-24110598 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    102
  • cDNA Data
    16
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74551 NCBI Gene Model | MGI Sequence Detail 9757 C57BL/6J ±  kb
    transcript NM_028994 RefSeq | MGI Sequence Detail 3420 C57BL/6  
    polypeptide Q8BH04 UniProt | EBI | MGI Sequence Detail 640 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000012417 phosphoenolpyruvate carboxykinase [GTP], mitochondrial
      (term hierarchy)
    • EC
      2.7.11.-, 4.1.1.32
    • InterPro Domains
      IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
      IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
      IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
      IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
      IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
      IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 6
      cDNA 16
      Primer pair 4
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916307, MGI:1921801
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 12
      Gene Ontology 16
      Phenotypes 17
    • Earliest
      J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
    • Latest
      J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory