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Wdr7 Gene Detail
Summary
  • Symbol
    Wdr7
  • Name
    WD repeat domain 7
  • Synonyms
    mKIAA0541, TGF-beta resistance associated gene, TRAG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860197
    NCBI Gene: 104082
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:63841756-64122847 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.09 cM, cytoband D1-E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7938 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860197
 protein coding gene Chr18:63841731-64122847 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024500
 protein coding gene Chr18:63717031-64018365 (+)
A/J MGP_AJ_G0024467
 protein coding gene Chr18:60986602-61267304 (+)
AKR/J MGP_AKRJ_G0024437
 protein coding gene Chr18:62686763-62968199 (+)
BALB/cJ MGP_BALBcJ_G0024466
 protein coding gene Chr18:61121021-61398616 (+)
C3H/HeJ MGP_C3HHeJ_G0024234
 protein coding gene Chr18:62911319-63194535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024913
 protein coding gene Chr18:65443663-65744781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022344
 protein coding gene Chr18:60444101-60716745 (+)
CAST/EiJ MGP_CASTEiJ_G0023707
 protein coding gene Chr18:62790996-63088166 (+)
CBA/J MGP_CBAJ_G0024204
 protein coding gene Chr18:67559594-67864353 (+)
DBA/2J MGP_DBA2J_G0024334
 protein coding gene Chr18:60646137-60927623 (+)
FVB/NJ MGP_FVBNJ_G0024300
 protein coding gene Chr18:60027052-60304860 (+)
LP/J MGP_LPJ_G0024418
 protein coding gene Chr18:63581852-63876380 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024329
 protein coding gene Chr18:69074955-69386737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024960
 protein coding gene Chr18:62880502-63175765 (+)
PWK/PhJ MGP_PWKPhJ_G0023450
 protein coding gene Chr18:60870720-61147323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023255
 protein coding gene Chr18:63057436-63352805 (+)
WSB/EiJ MGP_WSBEiJ_G0023771
 protein coding gene Chr18:62732632-63039978 (+)



Homology
more
  • Human Ortholog
    WDR7, WD repeat domain 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR7, WD repeat domain 7
  • Synonyms
    TRAG
  • Links
    NCBI Gene ID: 23335
    UniProt: Q9Y4E6

  • Chr Location
    18q21.31; chr18:56651343-57036606 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    13
  • cDNA Data
    50
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040560 Ensembl Gene Model | MGI Sequence Detail 281092 C57BL/6J ±  kb
transcript ENSMUST00000072726 Ensembl | MGI Sequence Detail 7135 Not Applicable  
polypeptide ENSMUSP00000072509 Ensembl | MGI Sequence Detail 1489 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000031394 WD repeat-containing protein 7
    (term hierarchy)
  • InterPro Domains
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR049916 WD repeat-containing protein 7/72
  • GlyGen
    Q920I9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 53
    Genomic 1
    cDNA 50
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147236
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:62790 Sanders S, et al., Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. Cytogenet Cell Genet. 2000;88(3-4):324-5
  • Latest
    J:360776 Di Michele M, et al., E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. Nat Commun. 2025 Jan 2;16(1):67
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory