Panx1 MGI Mouse Gene Detail - MGI:1860055

Symbol

Panx1
Name

pannexin 1

Feature Type

protein coding gene
IDs

MGI:1860055
NCBI Gene: 55991
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:14917081-14956774 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 4.52 cM
Mapping Data

3 experiments

SNPs within 2kb

1442 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860055	protein coding gene	Chr9:14913424-14956774 (-)
129S1/SvImJ	ENSMUSG00200048573	protein coding gene	Chr9:11815268-11858619 (-)
A/J	ENSMUSG00195032879	protein coding gene	Chr9:11700852-11744208 (-)
AKR/J	ENSMUSG00220026848	protein coding gene	Chr9:11678286-11721617 (-)
BALB/cJ	ENSMUSG00180040076	protein coding gene	Chr9:11824737-11868088 (-)
C3H/HeJ	ENSMUSG00175032516	protein coding gene	Chr9:11771760-11815106 (-)
C57BL/6NJ	ENSMUSG00215024859	protein coding gene	Chr9:11766354-11809707 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031791	protein coding gene	Chr9:11207736-11245635 (-)
CAST/EiJ	ENSTCUG00005028051	protein coding gene	Chr9:11806029-11848724 (-)
CBA/J	ENSMUSG00210043760	protein coding gene	Chr9:11802725-11846114 (-)
DBA/2J	ENSMUSG00185023734	protein coding gene	Chr9:11891438-11934789 (-)
FVB/NJ	ENSMUSG00205031416	protein coding gene	Chr9:11875477-11918829 (-)
JF1/MsJ	ENSUMUG00000028517	protein coding gene	Chr9:11885408-11928379 (-)
LP/J	ENSMUSG00230040329	protein coding gene	Chr9:12313359-12356708 (-)
NOD/ShiLtJ	ENSMUSG00190024593	protein coding gene	Chr9:11801953-11845302 (-)
NZO/HlLtJ	ENSMUSG00225049156	protein coding gene	Chr9:12202218-12245188 (-)
PWK/PhJ	ENSLUMG00010041560	protein coding gene	Chr9:11818675-11862339 (-)
SPRET/EiJ	ENSMSPG00010021256	protein coding gene	Chr9:11994301-12036412 (-)
WSB/EiJ	ENSIUOG00005036430	protein coding gene	Chr9:11470922-11514361 (-)

Human Ortholog

PANX1, pannexin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PANX1, pannexin 1
Synonyms

MRS1, OOMD7, OZEMA7, PX1, UNQ2529
Links

HGNC:8599

NCBI Gene ID: 24145

UniProt: Q96RD7
Chr Location

11q21; chr11:94128828-94181968 (+) GRCh38

MGI Vertebrate Homology

Panx1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PANX1
Gene Tree

Panx1

Diseases

1 with human PANX1 associations

				Human Disease	Mouse Models
				depressive disorder IDs depressive disorder DOID:1596 DOID:14672 ICD10CM:F33.9 MESH:D003863 NCI:C2982 UMLS_CUI:C0011570

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 6 alleles in 7 genetic backgrounds
3 phenotypes from multigenic genotypes
1 images
138 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

10
Gene trapped

1
Targeted

12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, ATP release by apoptotic thymocytes, hippocampal neurons, and astrocytes. Mice homozygous for a different knock-out allele exhibit protection from I/R-induced retinal ganglion cell loss.

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All GO Annotations

76
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

121
cDNA Data

54
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PANX1

Xenbase panx1

ZFIN panx1a, panx1b

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All Sequences

49
RefSeq

2
UniProt

5
CCDS

CCDS22832.1

Ensembl

ENSMUSG00000031934 (Evidence)
NCBI Gene

55991

			Length	Strain/Species	Flank
genomic	55991	NCBI Gene Model \| MGI Sequence Detail	39694	C57BL/6J	± kb
transcript	NM_019482	RefSeq \| MGI Sequence Detail	2112	C57BL/6
polypeptide	Q9JIP4	UniProt \| EBI \| MGI Sequence Detail	426	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012259 pannexin-1

(term hierarchy)
PDB

8A3B, 9HEV, 9HEW, 9HEX, 9HEY, 9HEZ, 9HF0, 9HF1, 9HF2, 9HF3
InterPro Domains

IPR000990 Innexin

IPR039099 Pannexin
GlyGen

Q9JIP4 1 site, 1 N-linked glycan (1 site)

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All nucleic 58

cDNA 54

Primer pair 4

Antibodies 3

Microarray probesets 3

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MGI:2143143

Summaries

All 238

Developmental Gene Expression 13

Gene Ontology 14

Phenotypes 138
Earliest

J:62853 Panchin Y, et al., A ubiquitous family of putative gap junction molecules. Curr Biol. 2000 Jun 29;10(13):R473-4
Latest

J:391248 Luan P, et al., A reciprocal glial circuit calibrates injury information and governs the tissue response balance. Neuron. 2026 Apr 15;

TSS for Panx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88227	Chr9:14956674-14956798 (-)	38 bp
Tssr88226	Chr9:14956441-14956452 (-)	327 bp
Tssr88225	Chr9:14956402-14956431 (-)	357 bp
Tssr88224	Chr9:14919190-14919197 (-)	37,580 bp
Tssr88223	Chr9:14919132-14919167 (-)	37,624 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24