Ebag9 MGI Mouse Gene Detail - MGI:1859920 - estrogen receptor-binding fragment-associated gene 9

Symbol

Ebag9
Name

estrogen receptor-binding fragment-associated gene 9
Synonyms

Rcas1

Feature Type

protein coding gene
IDs

MGI:1859920
NCBI Gene: 55960
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:44482571-44504911 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 16.91 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

566 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859920	protein coding gene	Chr15:44482571-44504916 (+)
129S1/SvImJ	ENSMUSG00200019146	protein coding gene	Chr15:41412755-41435123 (+)
A/J	ENSMUSG00195005388	protein coding gene	Chr15:41419833-41442177 (+)
AKR/J	ENSMUSG00220017881	protein coding gene	Chr15:41383447-41405798 (+)
BALB/cJ	ENSMUSG00180004455	protein coding gene	Chr15:41403199-41425541 (+)
C3H/HeJ	ENSMUSG00175019783	protein coding gene	Chr15:41641852-41664203 (+)
C57BL/6NJ	ENSMUSG00215003220	protein coding gene	Chr15:41417131-41439472 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019775	protein coding gene	Chr15:39125105-39148096 (+)
CAST/EiJ	ENSTCUG00005013530	protein coding gene	Chr15:41390308-41412674 (+)
CBA/J	ENSMUSG00210026357	protein coding gene	Chr15:41526233-41548596 (+)
DBA/2J	ENSMUSG00185012841	protein coding gene	Chr15:41491781-41514143 (+)
FVB/NJ	ENSMUSG00205012380	protein coding gene	Chr15:41439500-41461850 (+)
JF1/MsJ	ENSUMUG00000021652	protein coding gene	Chr15:41364813-41387164 (+)
LP/J	ENSMUSG00230014330	protein coding gene	Chr15:44796403-44818766 (+)
NOD/ShiLtJ	ENSMUSG00190008306	protein coding gene	Chr15:41463047-41485402 (+)
NZO/HlLtJ	ENSMUSG00225037490	protein coding gene	Chr15:45166035-45188368 (+)
PWK/PhJ	ENSLUMG00010011818	protein coding gene	Chr15:41548203-41570508 (+)
SPRET/EiJ	ENSMSPG00010006717	protein coding gene	Chr15:42426306-42451420 (+)
WSB/EiJ	ENSIUOG00005020482	protein coding gene	Chr15:41475567-41497913 (+)

Human Ortholog

EBAG9, estrogen receptor binding site associated antigen 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EBAG9, estrogen receptor binding site associated antigen 9
Synonyms

EB9, PDAF
Links

HGNC:3123

NCBI Gene ID: 9166

UniProt: O00559
Chr Location

8q23.2; chr8:109539702-109570072 (+) GRCh38

MGI Vertebrate Homology

Ebag9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EBAG9
Protein SuperFamily

RCAS1
Gene Tree

Ebag9

Diseases

1 with human EBAG9 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

5
Targeted

5
Genomic Mutations

2 involving Ebag9
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available

Homozygous null mice have decreased susceptibility to bacterial infections and have CD8⁺ T cells with enhanced cytolytic activity.

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All GO Annotations

8
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

666
Tissues

44
cDNA Data

30
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ebag9

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All Sequences

51
RefSeq

8
UniProt

2
CCDS

CCDS27457.1

Ensembl

ENSMUSG00000022339 (Evidence)
NCBI Gene

55960

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022339	Ensembl Gene Model \| MGI Sequence Detail	22341	C57BL/6J	± kb
transcript	ENSMUST00000227691	Ensembl \| MGI Sequence Detail	1945	Not Applicable
polypeptide	ENSMUSP00000154361	Ensembl \| MGI Sequence Detail	213	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006866 receptor-binding cancer antigen expressed on SiSo cells

(term hierarchy)
InterPro Domains

IPR017025 Cancer-associated antigen RCAS1

IPR060652 RCAS1, C-terminal

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All nucleic 31

cDNA 30

Primer pair 1

Antibodies 2

Microarray probesets 3

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MGI:2146065

Summaries

All 52

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:351223 Azuma K, et al., EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy. iScience. 2024 Feb 16;27(2):108871

TSS for Ebag9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131233	Chr15:44482667-44482724 (+)	125 bp
Tssr131234	Chr15:44482947-44483026 (+)	416 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24