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Dnaaf11 Gene Detail
Summary
  • Symbol
    Dnaaf11
  • Name
    dynein axonemal assembly factor 11
  • Synonyms
    Lrrc6, LRTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859553
    NCBI Gene: 54562
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:66251707-66372759 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 29.22 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    585 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859553
 protein coding gene Chr15:66251707-66372769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021904
 protein coding gene Chr15:65883704-66003815 (-)
A/J MGP_AJ_G0021863
 protein coding gene Chr15:63383294-63507914 (-)
AKR/J MGP_AKRJ_G0021845
 protein coding gene Chr15:65146540-65268945 (-)
BALB/cJ MGP_BALBcJ_G0021870
 protein coding gene Chr15:63569148-63689538 (-)
C3H/HeJ MGP_C3HHeJ_G0021643
 protein coding gene Chr15:65258711-65384980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022309
 protein coding gene Chr15:68443332-68577838 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019846
 protein coding gene Chr15:60173666-60288486 (-)
CAST/EiJ MGP_CASTEiJ_G0021162
 protein coding gene Chr15:65917994-66042261 (-)
CBA/J MGP_CBAJ_G0021609
 protein coding gene Chr15:70718125-70845521 (-)
DBA/2J MGP_DBA2J_G0021734
 protein coding gene Chr15:63174403-63295519 (-)
FVB/NJ MGP_FVBNJ_G0021716
 protein coding gene Chr15:62208054-62332609 (-)
LP/J MGP_LPJ_G0021806
 protein coding gene Chr15:65778433-65899691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021739
 protein coding gene Chr15:75804688-75943753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022331
 protein coding gene Chr15:65519759-65645466 (-)
PWK/PhJ MGP_PWKPhJ_G0020903
 protein coding gene Chr15:63257628-63385181 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020744
 protein coding gene Chr15:65375939-65503357 (-)
WSB/EiJ MGP_WSBEiJ_G0021214
 protein coding gene Chr15:65487497-65612273 (-)



Homology
more
  • Human Ortholog
    DNAAF11, dynein axonemal assembly factor 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAAF11, dynein axonemal assembly factor 11
  • Synonyms
    CILD19, LRRC6, LRTP, tilB, TSLRP
  • Links
    NCBI Gene ID: 23639
    neXtProt AC: NX_Q86X45
    UniProt: Q86X45

  • Chr Location
    8q24.22; chr8:132570416-132702913 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnaaf11 mouse models; 1 with human DNAAF11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial prenatal lethality, variable laterality defects, hydrocephaly, loss of motility in various motile cilia, absence of outer dynein arms in tracheal cilia, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022375 Ensembl Gene Model | MGI Sequence Detail 121053 C57BL/6J ±  kb
    transcript ENSMUST00000023006 Ensembl | MGI Sequence Detail 2084 Not Applicable  
    polypeptide ENSMUSP00000023006 Ensembl | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:337654 Kim DY, et al., LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus. Cell Commun Signal. 2023 Jun 16;21(1):142
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory