Prc1 MGI Mouse Gene Detail - MGI:1858961 - protein regulator of cytokinesis 1

Symbol

Prc1
Name

protein regulator of cytokinesis 1
Synonyms

D7Ertd348e, MGC:6745

Feature Type

protein coding gene
IDs

MGI:1858961
NCBI Gene: 233406
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:79944224-79966007 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.62 cM
Mapping Data

4 experiments

SNPs within 2kb

769 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858961	protein coding gene	Chr7:79944198-79966007 (+)
129S1/SvImJ	ENSMUSG00200032474	protein coding gene	Chr7:66762559-66784229 (+)
A/J	ENSMUSG00195036842	protein coding gene	Chr7:71175491-71197250 (+)
AKR/J	ENSMUSG00220033808	protein coding gene	Chr7:64717510-64739262 (+)
BALB/cJ	ENSMUSG00180012567	protein coding gene	Chr7:67900589-67922350 (+)
C3H/HeJ	ENSMUSG00175019654	protein coding gene	Chr7:68674650-68696321 (+)
C57BL/6NJ	ENSMUSG00215019385	protein coding gene	Chr7:67770349-67792159 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029901	protein coding gene	Chr7:82857872-82880286 (+)
CAST/EiJ	ENSTCUG00005044757	protein coding gene	Chr7:71220742-71242974 (+)
CBA/J	ENSMUSG00210023331	protein coding gene	Chr7:68525898-68547552 (+)
DBA/2J	ENSMUSG00185042040	protein coding gene	Chr7:72848682-72870352 (+)
FVB/NJ	ENSMUSG00205023078	protein coding gene	Chr7:68408672-68430425 (+)
JF1/MsJ	ENSUMUG00000009673	protein coding gene	Chr7:77508169-77530347 (+)
LP/J	ENSMUSG00230011752	protein coding gene	Chr7:78938158-78959828 (+)
NOD/ShiLtJ	ENSMUSG00190017024	protein coding gene	Chr7:68665880-68687550 (+)
NZO/HlLtJ	ENSMUSG00225041567	protein coding gene	Chr7:77177572-77199322 (+)
PWK/PhJ	ENSLUMG00010017033	protein coding gene	Chr7:67099536-67121949 (+)
SPRET/EiJ	ENSMSPG00010022638	protein coding gene	Chr7:67506822-67529194 (+)
WSB/EiJ	ENSIUOG00005018415	protein coding gene	Chr7:69014041-69035774 (+)

Human Ortholog

PRC1, protein regulator of cytokinesis 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRC1, protein regulator of cytokinesis 1
Synonyms

ASE1, MAP65
Links

HGNC:9341

NCBI Gene ID: 9055

UniProt: O43663
Chr Location

15q26.1; chr15:90966038-90995629 (-) GRCh38

MGI Vertebrate Homology

Prc1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRC1
Gene Tree

Prc1

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Phenotype Summary

11 phenotypes from 3 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

16
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Prc1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit embryonic lethality.

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All GO Annotations

34
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

137
cDNA Data

203
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prc1, prc1.2

ZFIN prc1b

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All Sequences

94
RefSeq

22
UniProt

11
CCDS

CCDS39998.2, CCDS71985.1, CCDS71986.1, CCDS90258.1

Ensembl

ENSMUSG00000038943 (Evidence)
NCBI Gene

233406

			Length	Strain/Species	Flank
genomic	233406	NCBI Gene Model \| MGI Sequence Detail	21784	C57BL/6J	± kb
transcript	NM_001374624	RefSeq \| MGI Sequence Detail	3042	ZRU/MplStud
polypeptide	Q99K43	UniProt \| EBI \| MGI Sequence Detail	603	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000013176 protein regulator of cytokinesis 1

(term hierarchy)
InterPro Domains

IPR007145 Microtubule-associated protein, MAP65/Ase1/PRC1

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All nucleic 209

cDNA 205

Primer pair 3

Other 1

Microarray probesets 5

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MGI:1289307

Summaries

All 81

Developmental Gene Expression 14

Gene Ontology 8

Phenotypes 26
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:382756 Zhou S, et al., hnRNPM cooperates with BCAS2 to modulate alternative splicing during oocyte development. Nat Commun. 2026 Feb 12;17(1)

TSS for Prc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67432	Chr7:79944207-79944240 (+)	0 bp
Tssr67433	Chr7:79944289-79944298 (+)	70 bp
Tssr67434	Chr7:79944305-79944313 (+)	85 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24