Rasa4 MGI Mouse Gene Detail - MGI:1858600 - RAS p21 protein activator 4

Symbol

Rasa4
Name

RAS p21 protein activator 4

Feature Type

protein coding gene
IDs

MGI:1858600
NCBI Gene: 54153
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr5:136112775-136140714 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 75.76 cM
Mapping Data

3 experiments

SNPs within 2kb

1694 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858600	protein coding gene	Chr5:136112770-136140714 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030199	protein coding gene	Chr5:140703852-140737027 (+)
A/J	MGP_AJ_G0030167	protein coding gene	Chr5:134648135-134677823 (+)
AKR/J	MGP_AKRJ_G0030100	protein coding gene	Chr5:139001120-139030721 (+)
BALB/cJ	MGP_BALBcJ_G0030177	protein coding gene	Chr5:136004007-136035594 (+)
C3H/HeJ	MGP_C3HHeJ_G0029893	protein coding gene	Chr5:139616516-139651124 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030630	protein coding gene	Chr5:145937189-145966773 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027850	protein coding gene	Chr5:128935120-128963173 (+)
CAST/EiJ	MGP_CASTEiJ_G0029303	protein coding gene	Chr5:139019315-139051016 (+)
CBA/J	MGP_CBAJ_G0029863	protein coding gene	Chr5:151632672-151677227 (+)
DBA/2J	MGP_DBA2J_G0030014	protein coding gene	Chr5:134550447-134578092 (+)
FVB/NJ	MGP_FVBNJ_G0029969	protein coding gene	Chr5:133703003-133732170 (+)
LP/J	MGP_LPJ_G0030103	protein coding gene	Chr5:141131014-141163458 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030001	protein coding gene	Chr5:154614846-154646307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030670	protein coding gene	Chr5:138813014-138841784 (+)
PWK/PhJ	MGP_PWKPhJ_G0029016	protein coding gene	Chr5:133610536-133637116 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028852	protein coding gene	Chr5:136365100-136396849 (+)
WSB/EiJ	MGP_WSBEiJ_G0029376	protein coding gene	Chr5:139537793-139570873 (+)

Human Ortholog

RASA4, RAS p21 protein activator 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASA4, RAS p21 protein activator 4
Synonyms

CAPRI, GAPL
Links

HGNC:23181

NCBI Gene ID: 10156

UniProt: O43374
Chr Location

7q22.1; chr7:102579646-102616758 (-) GRCh38

Human Ortholog

RASA4B, RAS p21 protein activator 4B
Links

HGNC:35202

NCBI Gene ID: 100271927

UniProt: C9J798
Chr Location

7q22.1; chr7:102479976-102517777 (-) GRCh38

MGI Vertebrate Homology

Rasa4 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RASA4, RASA4B
Gene Tree

Rasa4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

9
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for disruptions in this gene display an increased sensitivity to bacterial infections which involves reduced phagocyte function.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

2
cDNA Data

42
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rasa4

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All Sequences

78
RefSeq

17
UniProt

4
CCDS

CCDS39324.1, CCDS39325.1

Ensembl

ENSMUSG00000004952 (Evidence)
NCBI Gene

54153

			Length	Strain/Species	Flank
genomic	54153	NCBI Gene Model \| MGI Sequence Detail	27940	C57BL/6J	± kb
transcript	NM_133914	RefSeq \| MGI Sequence Detail	2840	C57BL/6
polypeptide	Q6PFQ7	UniProt \| EBI \| MGI Sequence Detail	802	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR037777 RASA4, PH domain

IPR001936 Ras GTPase-activating domain

IPR039360 Ras GTPase-activating protein

IPR023152 Ras GTPase-activating protein, conserved site

IPR008936 Rho GTPase activation protein

IPR001562 Zinc finger, Btk motif
GlyGen

Q6PFQ7 1 site, 1 O-linked glycan (1 site)

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All nucleic 45

cDNA 43

Primer pair 2

Microarray probesets 4

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MGI:2141155, MGI:2141261

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 5
Earliest

J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Rasa4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49225	Chr5:136112765-136112774 (+)	-5 bp
Tssr49226	Chr5:136112796-136112864 (+)	55 bp
Tssr49227	Chr5:136112876-136112892 (+)	109 bp
Tssr49228	Chr5:136112937-136112955 (+)	171 bp
Tssr49229	Chr5:136118522-136118533 (+)	5,753 bp
Tssr49230	Chr5:136118691-136118705 (+)	5,923 bp
Tssr49231	Chr5:136118802-136118818 (+)	6,035 bp
Tssr49232	Chr5:136120081-136120118 (+)	7,325 bp
Tssr49233	Chr5:136122148-136122155 (+)	9,377 bp
Tssr49234	Chr5:136125300-136125309 (+)	12,530 bp
Tssr49235	Chr5:136125724-136125738 (+)	12,956 bp
Tssr49236	Chr5:136128469-136128475 (+)	15,697 bp
Tssr49237	Chr5:136131177-136131232 (+)	18,430 bp
Tssr49238	Chr5:136132217-136132228 (+)	19,448 bp
Tssr49239	Chr5:136139394-136139417 (+)	26,631 bp
Tssr49240	Chr5:136139427-136139451 (+)	26,664 bp
Tssr49241	Chr5:136139460-136139483 (+)	26,697 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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