Ddx20 MGI Mouse Gene Detail - MGI:1858415

Symbol

Ddx20
Name

DEAD box helicase 20
Synonyms

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20, dp103, GEMIN3

Feature Type

protein coding gene
IDs

MGI:1858415
NCBI Gene: 53975
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:105585586-105594890 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.43 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

69 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858415	protein coding gene	Chr3:105585586-105595104 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027718	protein coding gene	Chr3:107053163-107062379 (-)
A/J	MGP_AJ_G0027678	protein coding gene	Chr3:103626136-103635403 (-)
AKR/J	MGP_AKRJ_G0027643	protein coding gene	Chr3:106199196-106210202 (-)
BALB/cJ	MGP_BALBcJ_G0027690	protein coding gene	Chr3:103410835-103419930 (-)
C3H/HeJ	MGP_C3HHeJ_G0027420	protein coding gene	Chr3:106539155-106548410 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028134	protein coding gene	Chr3:111053397-111063856 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025474	protein coding gene	Chr3:99705883-99714790 (-)
CAST/EiJ	MGP_CASTEiJ_G0026876	protein coding gene	Chr3:105690121-105699167 (-)
CBA/J	MGP_CBAJ_G0027395	protein coding gene	Chr3:114795409-114804654 (-)
DBA/2J	MGP_DBA2J_G0027537	protein coding gene	Chr3:102865879-102875350 (-)
FVB/NJ	MGP_FVBNJ_G0027505	protein coding gene	Chr3:100798995-100808395 (-)
LP/J	MGP_LPJ_G0027644	protein coding gene	Chr3:108454629-108463826 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027535	protein coding gene	Chr3:120910346-120919441 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028189	protein coding gene	Chr3:105748543-105757650 (-)
PWK/PhJ	MGP_PWKPhJ_G0026602	protein coding gene	Chr3:102647544-102656963 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026423	protein coding gene	Chr3:103780559-103789620 (-)
WSB/EiJ	MGP_WSBEiJ_G0026956	protein coding gene	Chr3:106309867-106318943 (-)

Human Ortholog

DDX20, DEAD-box helicase 20

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX20, DEAD-box helicase 20
Synonyms

DP103, GEMIN3
Links

HGNC:2743

NCBI Gene ID: 11218

neXtProt AC: NX_Q9UHI6

UniProt: Q9UHI6
Chr Location

1p13.2; chr1:111754832-111775602 (+) GRCh38

MGI Vertebrate Homology

Ddx20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX20
Gene Tree

Ddx20

less

References

1 with disease annotations

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ddx20
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele fail to implant and develop past the 2-cell stage. Heterozygous null females are viable, healthy and fertile but show increased ovary weight, a greater number of empty follicles, a prolonged estrous phase, and reduced nocturnal and stress-induced serum ACTH levels.

less

All GO Annotations

37
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

26
cDNA Data

83
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx20

less

All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS38581.1

Ensembl

ENSMUSG00000027905 (Evidence)
NCBI Gene

53975

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027905	Ensembl Gene Model \| MGI Sequence Detail	9305	C57BL/6J	± kb
transcript	ENSMUST00000090680	Ensembl \| MGI Sequence Detail	2905	Not Applicable
polypeptide	ENSMUSP00000088176	Ensembl \| MGI Sequence Detail	825	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000029384 probable ATP-dependent RNA helicase DDX20

(term hierarchy)
EC

3.6.1.15, 3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

less

All nucleic 86

cDNA 84

Other 2

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 4

Diseases 1

Gene Ontology 12

Phenotypes 14
Earliest

J:61764 Campbell L, et al., Direct interaction of Smn with dp103, a putative RNA helicase: a role for Smn in transcription regulation?. Hum Mol Genet. 2000 Apr 12;9(7):1093-100
Latest

J:319558 Bizen N, et al., Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022;

TSS for Ddx20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34927	Chr3:105595060-105595088 (-)	-184 bp
Tssr34926	Chr3:105595041-105595056 (-)	-159 bp
Tssr34925	Chr3:105594868-105594907 (-)	2 bp
Tssr34924	Chr3:105594737-105594773 (-)	135 bp
Tssr34923	Chr3:105594692-105594725 (-)	181 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23