About   Help   FAQ
Ear4 Gene Detail
Summary
  • Symbol
    Ear4
  • Name
    eosinophil-associated, ribonuclease A family, member 4
  • Synonyms
    liver, eosinophil-derived neurotoxin, mR4, ribonuclease 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858238
    NCBI Gene: 53877
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:51441154-51441613 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858238
 protein coding gene Chr14:51441154-51441613 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Synonyms
    EDN, RAF3, RNS2
  • Links
    NCBI Gene ID: 6036
    neXtProt AC: NX_P10153
    UniProt: P10153

  • Chr Location
    14q11.2; chr14:20955487-20956436 (+)  GRCh38
  • Human Ortholog
    RNASE3, ribonuclease A family member 3
  • Synonyms
    ECP, RAF1, RNS3
  • Links
    NCBI Gene ID: 6037
    neXtProt AC: NX_P12724
    UniProt: P12724

  • Chr Location
    14q11.2; chr14:20891385-20892348 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Other Mouse Links
    GEO
Sequences &
Gene Models
less
  • All Sequences
    5
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic AF017259 GenBank | ENA | DDBJ | MGI Sequence Detail 468 Not Specified ±  kb
transcript NM_001017422 RefSeq | MGI Sequence Detail 468 Not Specified  
polypeptide O35291 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 15
    Gene Ontology 6
  • Earliest
    J:44252 Batten D, et al., Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family. Nucleic Acids Res. 1997 Nov 1;25(21):4235-9
  • Latest
    J:95949 Cho S, et al., The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Genomics. 2005 Feb;85(2):208-20
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory