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Celsr3 Gene Detail
Summary
  • Symbol
    Celsr3
  • Name
    cadherin, EGF LAG seven-pass G-type receptor 3
  • Synonyms
    Adgrc3, flamingo, Fmi1, mKIAA0812
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858236
    NCBI Gene: 107934
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108703519-108730168 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858236
 protein coding gene Chr9:108703244-108730168 (+)
129S1/SvImJ ENSMUSG00200039782
 protein coding gene Chr9:105899793-105926446 (+)
A/J ENSMUSG00195041298
 protein coding gene Chr9:105118989-105145657 (+)
AKR/J ENSMUSG00220026704
 protein coding gene Chr9:105506284-105532972 (+)
BALB/cJ ENSMUSG00180022442
 protein coding gene Chr9:105435448-105462127 (+)
C3H/HeJ ENSMUSG00175040999
 protein coding gene Chr9:105777711-105804383 (+)
C57BL/6NJ ENSMUSG00215039193
 protein coding gene Chr9:105756360-105783009 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032705
 protein coding gene Chr9:104161604-104188460 (+)
CAST/EiJ ENSTCUG00005033371
 protein coding gene Chr9:105531822-105558621 (+)
CBA/J ENSMUSG00210039812
 protein coding gene Chr9:105631287-105658074 (+)
DBA/2J ENSMUSG00185031435
 protein coding gene Chr9:105787136-105813813 (+)
FVB/NJ ENSMUSG00205043459
 protein coding gene Chr9:105788521-105815190 (+)
JF1/MsJ ENSUMUG00000052178
 protein coding gene Chr9:105620596-105647395 (+)
LP/J ENSMUSG00230047902
 protein coding gene Chr9:105928602-105955259 (+)
NOD/ShiLtJ ENSMUSG00190032195
 protein coding gene Chr9:105425548-105452220 (+)
NZO/HlLtJ ENSMUSG00225022410
 protein coding gene Chr9:106160340-106186998 (+)
PWK/PhJ ENSLUMG00010041517
 protein coding gene Chr9:105584347-105611149 (+)
SPRET/EiJ ENSMSPG00010035803
 protein coding gene Chr9:107410483-107437229 (+)
WSB/EiJ ENSIUOG00005041233
 protein coding gene Chr9:104876736-104903346 (+)



Homology
more
  • Human Ortholog
    CELSR3, cadherin EGF LAG seven-pass G-type receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CELSR3, cadherin EGF LAG seven-pass G-type receptor 3
  • Synonyms
    ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
  • Links
    NCBI Gene ID: 1951
    UniProt: Q9NYQ7

  • Chr Location
    3p21.31; chr3:48636463-48662886 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    141
  • cDNA Data
    39
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023473 Ensembl Gene Model | MGI Sequence Detail 26650 C57BL/6J ±  kb
    transcript ENSMUST00000213524 Ensembl | MGI Sequence Detail 11571 Not Applicable  
    polypeptide ENSMUSP00000150759 Ensembl | MGI Sequence Detail 3309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 39
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 36
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
    • Latest
      J:387698 Nasello C, et al., A Celsr3 Mutation Linked to Tourette Disorder Disrupts Cortical Dendritic Patterning and Striatal Cholinergic Interneuron Excitability. Int J Mol Sci. 2025 Oct 23;26(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory