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Ppp1r3c Gene Detail
Summary
  • Symbol
    Ppp1r3c
  • Name
    protein phosphatase 1, regulatory subunit 3C
  • Synonyms
    Ppp1r5, protein targeting to glicogen, PTG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858229
    NCBI Gene: 53412
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:36709131-36714004 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 31.89 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858229
 protein coding gene Chr19:36709131-36714053 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025073
 protein coding gene Chr19:35627998-35632914 (-)
A/J MGP_AJ_G0025049
 protein coding gene Chr19:33927605-33932521 (-)
AKR/J MGP_AKRJ_G0025017
 protein coding gene Chr19:35060521-35065437 (-)
BALB/cJ MGP_BALBcJ_G0025047
 protein coding gene Chr19:34011124-34016040 (-)
C3H/HeJ MGP_C3HHeJ_G0024806
 protein coding gene Chr19:35127313-35132229 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025488
 protein coding gene Chr19:36661711-36666627 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022906
 protein coding gene Chr19:33301490-33306409 (-)
CAST/EiJ MGP_CASTEiJ_G0024273
 protein coding gene Chr19:34953694-34958681 (-)
CBA/J MGP_CBAJ_G0024783
 protein coding gene Chr19:38387314-38392230 (-)
DBA/2J MGP_DBA2J_G0024915
 protein coding gene Chr19:33786105-33791021 (-)
FVB/NJ MGP_FVBNJ_G0024876
 protein coding gene Chr19:33592983-33597897 (-)
LP/J MGP_LPJ_G0025001
 protein coding gene Chr19:35720409-35725325 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024907
 protein coding gene Chr19:38219753-38224669 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025546
 protein coding gene Chr19:35159930-35164846 (-)
PWK/PhJ MGP_PWKPhJ_G0024025
 protein coding gene Chr19:33611960-33616964 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023825
 protein coding gene Chr19:33994417-33999336 (-)
WSB/EiJ MGP_WSBEiJ_G0024340
 protein coding gene Chr19:35255317-35260233 (-)



Homology
more
  • Human Ortholog
    PPP1R3C, protein phosphatase 1 regulatory subunit 3C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R3C, protein phosphatase 1 regulatory subunit 3C
  • Synonyms
    PPP1R5, PTG
  • Links
    NCBI Gene ID: 5507
    neXtProt AC: NX_Q9UQK1
    UniProt: Q9UQK1

  • Chr Location
    10q23.32; chr10:91628442-91633071 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppp1r3c mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are embyronic lethal. Heterozygotes have reduced glycogen stores, attenuated glycogen synthesis, glucose intolerance, hyperinsulinemia and insulin resistance. Mice homozygous for a different knock-out allele exhibit normal lifespan with enhanced whole body insulin sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    54
  • cDNA Data
    37
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53412 NCBI Gene Model | MGI Sequence Detail 4874 C57BL/6J ±  kb
    transcript NM_016854 RefSeq | MGI Sequence Detail 2696 C57BL/6  
    polypeptide Q7TMB3 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000013126 protein phosphatase 1 regulatory subunit 3C
      (term hierarchy)
    • InterPro Domains
      IPR005036 CBM21 (carbohydrate binding type-21) domain
      IPR038175 CBM21 domain superfamily
      IPR017434 Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
      IPR030683 Protein phosphatase 1 regulatory subunit 3C
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:38865 Printen JA, et al., PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997 Mar 7;275(5305):1475-8
    • Latest
      J:334038 Nitschke S, et al., Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency. Brain. 2022 Jul 29;145(7):2361-2377
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory