Stx7 MGI Mouse Gene Detail - MGI:1858210

Symbol

Stx7
Name

syntaxin 7

Feature Type

protein coding gene
IDs

MGI:1858210
NCBI Gene: 53331
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:24025182-24064859 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 11.45 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

1071 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858210	protein coding gene	Chr10:24025182-24066120 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017090	protein coding gene	Chr10:22103568-22145467 (+)
A/J	MGP_AJ_G0017067	protein coding gene	Chr10:21455150-21496037 (+)
AKR/J	MGP_AKRJ_G0017027	protein coding gene	Chr10:21804948-21844975 (+)
BALB/cJ	MGP_BALBcJ_G0017030	protein coding gene	Chr10:21541228-21581694 (+)
C3H/HeJ	MGP_C3HHeJ_G0016850	protein coding gene	Chr10:22019931-22061050 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017488	protein coding gene	Chr10:22794911-22836639 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015186	protein coding gene	Chr10:20173306-20215262 (+)
CAST/EiJ	MGP_CASTEiJ_G0016429	protein coding gene	Chr10:21938749-21981869 (+)
CBA/J	MGP_CBAJ_G0016824	protein coding gene	Chr10:23818781-23865987 (+)
DBA/2J	MGP_DBA2J_G0016929	protein coding gene	Chr10:21191104-21232420 (+)
FVB/NJ	MGP_FVBNJ_G0016924	protein coding gene	Chr10:20908916-20948158 (+)
LP/J	MGP_LPJ_G0017006	protein coding gene	Chr10:22108335-22150346 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016954	protein coding gene	Chr10:23934987-23980445 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017524	protein coding gene	Chr10:21677469-21717681 (+)
PWK/PhJ	MGP_PWKPhJ_G0016211	protein coding gene	Chr10:20969539-21010539 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015995	protein coding gene	Chr10:21487306-21527838 (+)
WSB/EiJ	MGP_WSBEiJ_G0016492	protein coding gene	Chr10:21782520-21823837 (+)

Human Ortholog

STX7, syntaxin 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX7, syntaxin 7
Links

HGNC:11442

NCBI Gene ID: 8417

neXtProt AC: NX_O15400

UniProt: O15400
Chr Location

6q23.2; chr6:132445867-132513472 (-) GRCh38

MGI Vertebrate Homology

Stx7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STX7
Gene Tree

Stx7

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Genomic Mutations

1 involving Stx7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

45
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

15
cDNA Data

126
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stx7

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All Sequences

80
RefSeq

6
UniProt

4
CCDS

CCDS23749.1

Ensembl

ENSMUSG00000019998 (Evidence)
NCBI Gene

53331

			Length	Strain/Species	Flank
genomic	53331	NCBI Gene Model \| MGI Sequence Detail	39678	C57BL/6J	± kb
transcript	NM_016797	RefSeq \| MGI Sequence Detail	2510	C57BL/6
polypeptide	O70439	UniProt \| EBI \| MGI Sequence Detail	261	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015799 syntaxin-7

(term hierarchy)
PDB

1GL2
InterPro Domains

IPR010989 SNARE

IPR045242 Syntaxin

IPR006012 Syntaxin/epimorphin, conserved site

IPR006011 Syntaxin, N-terminal domain

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 126

cDNA 126

Microarray probesets 5

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MGI:2143566, MGI:2143572, MGI:2143805

Summaries

All 57

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stx7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92720	Chr10:24025189-24025274 (+)	50 bp
Tssr92721	Chr10:24025342-24025365 (+)	172 bp
Tssr92722	Chr10:24025425-24025475 (+)	268 bp
Tssr92723	Chr10:24026834-24026869 (+)	1,670 bp
Tssr92724	Chr10:24027039-24027069 (+)	1,872 bp
Tssr92725	Chr10:24064683-24064700 (+)	39,510 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/01/2024 MGI 6.24