Ech1 MGI Mouse Gene Detail - MGI:1858208 - enoyl coenzyme A hydratase 1, peroxisomal

Symbol

Ech1
Name

enoyl coenzyme A hydratase 1, peroxisomal
Synonyms

dienoyl-CoA isomerase

Feature Type

protein coding gene
IDs

MGI:1858208
NCBI Gene: 51798
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:28524763-28531664 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM
Mapping Data

2 experiments

SNPs within 2kb

330 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858208	protein coding gene	Chr7:28524642-28531672 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031963	protein coding gene	Chr7:27669841-27678265 (+)
A/J	MGP_AJ_G0031941	protein coding gene	Chr7:26974660-26983542 (+)
AKR/J	MGP_AKRJ_G0031873	protein coding gene	Chr7:27668745-27677554 (+)
BALB/cJ	MGP_BALBcJ_G0031948	protein coding gene	Chr7:27132213-27139678 (+)
C3H/HeJ	MGP_C3HHeJ_G0031667	protein coding gene	Chr7:28043926-28052294 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032412	protein coding gene	Chr7:28575392-28583980 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029464	protein coding gene	Chr7:28036034-28042966 (+)
CAST/EiJ	MGP_CASTEiJ_G0031002	protein coding gene	Chr7:21364972-21373450 (+)
CBA/J	MGP_CBAJ_G0031633	protein coding gene	Chr7:29849359-29874815 (+)
DBA/2J	MGP_DBA2J_G0031785	protein coding gene	Chr7:26726261-26733281 (+)
FVB/NJ	MGP_FVBNJ_G0031742	protein coding gene	Chr7:26810112-26816752 (+)
LP/J	MGP_LPJ_G0031865	protein coding gene	Chr7:27996840-28004941 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031778	protein coding gene	Chr7:29314735-29323311 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032442	protein coding gene	Chr7:27149470-27157727 (+)
PWK/PhJ	MGP_PWKPhJ_G0030727	protein coding gene	Chr7:21751019-21758319 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030560	protein coding gene	Chr7:18172171-18180914 (+)
WSB/EiJ	MGP_WSBEiJ_G0031111	protein coding gene	Chr7:27517323-27526217 (+)

Human Ortholog

ECH1, enoyl-CoA hydratase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ECH1, enoyl-CoA hydratase 1
Synonyms

HPXEL
Links

HGNC:3149

NCBI Gene ID: 1891

neXtProt AC: NX_Q13011

UniProt: Q13011
Chr Location

19q13.2; chr19:38815422-38831841 (-) GRCh38

MGI Vertebrate Homology

Ech1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ECH1
Gene Tree

Ech1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

6
Targeted

4
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

261
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ech1

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS21057.1

Ensembl

ENSMUSG00000053898 (Evidence)
NCBI Gene

51798

			Length	Strain/Species	Flank
genomic	51798	NCBI Gene Model \| MGI Sequence Detail	6902	C57BL/6J	± kb
transcript	NM_016772	RefSeq \| MGI Sequence Detail	1138	Not Specified
polypeptide	O35459	UniProt \| EBI \| MGI Sequence Detail	327	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006877 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

(term hierarchy)
EC

5.3.3.-
InterPro Domains

IPR029045 ClpP/crotonase-like domain superfamily

IPR045002 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like

IPR014748 Enoyl-CoA hydratase, C-terminal

IPR001753 Enoyl-CoA hydratase/isomerase

IPR018376 Enoyl-CoA hydratase/isomerase, conserved site
GlyGen

O35459 1 site, 1 O-linked glycan (1 site)

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All nucleic 263

cDNA 261

Primer pair 2

Microarray probesets 3

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MGI:2141846

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 14
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ech1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65547	Chr7:28524627-28524640 (+)	-129 bp
Tssr65548	Chr7:28524698-28524710 (+)	-59 bp
Tssr65549	Chr7:28524726-28524739 (+)	-30 bp
Tssr65550	Chr7:28524743-28524788 (+)	3 bp
Tssr65551	Chr7:28526947-28526949 (+)	2,185 bp
Tssr65552	Chr7:28527056-28527057 (+)	2,294 bp
Tssr65553	Chr7:28529432-28529453 (+)	4,680 bp
Tssr65554	Chr7:28529512-28529517 (+)	4,752 bp
Tssr65555	Chr7:28529532-28529562 (+)	4,784 bp
Tssr65556	Chr7:28529567-28529581 (+)	4,811 bp
Tssr65557	Chr7:28530800-28530814 (+)	6,044 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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