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Prg3 Gene Detail
Summary
  • Symbol
    Prg3
  • Name
    proteoglycan 3
  • Synonyms
    major basic protein 2, MBP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858200
    NCBI Gene: 53856
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84818559-84824230 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858200
protein coding gene Chr2:84818540-84826903 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025918
protein coding gene Chr2:85694365-85700013 (+)
A/J MGP_AJ_G0025892
protein coding gene Chr2:82372977-82378587 (+)
AKR/J MGP_AKRJ_G0025862
protein coding gene Chr2:84503832-84511218 (+)
BALB/cJ MGP_BALBcJ_G0025889
protein coding gene Chr2:82503519-82509131 (+)
C3H/HeJ MGP_C3HHeJ_G0025648
protein coding gene Chr2:84734941-84740500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026335
protein coding gene Chr2:88348768-88355862 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023737
protein coding gene Chr2:79200366-79206397 (+)
CAST/EiJ MGP_CASTEiJ_G0025109
protein coding gene Chr2:85282795-85291191 (+)
CBA/J MGP_CBAJ_G0025629
protein coding gene Chr2:91500039-91505648 (+)
DBA/2J MGP_DBA2J_G0025760
protein coding gene Chr2:81910045-81915845 (+)
FVB/NJ MGP_FVBNJ_G0025723
protein coding gene Chr2:81165012-81170632 (+)
LP/J MGP_LPJ_G0025848
protein coding gene Chr2:85485508-85491812 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025753
protein coding gene Chr2:93820875-93826507 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026391
protein coding gene Chr2:84751790-84757410 (+)
PWK/PhJ MGP_PWKPhJ_G0024853
protein coding gene Chr2:81754456-81760689 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024657
protein coding gene Chr2:84873467-84879470 (+)
WSB/EiJ MGP_WSBEiJ_G0025179
protein coding gene Chr2:85409906-85417362 (+)



Homology
more
  • Human Ortholog
    PRG3, proteoglycan 3, pro eosinophil major basic protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRG3, proteoglycan 3, pro eosinophil major basic protein 2
  • Synonyms
    MBP2, MBPH
  • Links
    NCBI Gene ID: 10394
    neXtProt AC: NX_Q9Y2Y8
    UniProt: Q9Y2Y8

  • Chr Location
    11q12.1; chr11:57376769-57381150 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027072 Ensembl Gene Model | MGI Sequence Detail 5672 C57BL/6J ±  kb
    transcript ENSMUST00000028466 Ensembl | MGI Sequence Detail 949 Not Applicable  
    polypeptide ENSMUSP00000028466 Ensembl | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 8
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:61440 Macias MP, et al., Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2. J Leukoc Biol. 2000 Apr;67(4):567-76
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory