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Grb14 Gene Detail
Summary
  • Symbol
    Grb14
  • Name
    growth factor receptor bound protein 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355324
    NCBI Gene: 50915
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:64742820-64853354 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 38.35 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    675 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355324
 protein coding gene Chr2:64742820-64855331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025776
 protein coding gene Chr2:64679673-64802109 (-)
A/J MGP_AJ_G0025752
 protein coding gene Chr2:62205051-62319202 (-)
AKR/J MGP_AKRJ_G0025722
 protein coding gene Chr2:63863036-63976990 (-)
BALB/cJ MGP_BALBcJ_G0025747
 protein coding gene Chr2:62350489-62467633 (-)
C3H/HeJ MGP_C3HHeJ_G0025508
 protein coding gene Chr2:64018685-64141940 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026194
 protein coding gene Chr2:66583249-66717982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023598
 protein coding gene Chr2:59576533-59687401 (-)
CAST/EiJ MGP_CASTEiJ_G0024972
 protein coding gene Chr2:64059494-64179685 (-)
CBA/J MGP_CBAJ_G0025488
 protein coding gene Chr2:69142615-69259830 (-)
DBA/2J MGP_DBA2J_G0025619
 protein coding gene Chr2:61822707-61937051 (-)
FVB/NJ MGP_FVBNJ_G0025581
 protein coding gene Chr2:61246382-61362631 (-)
LP/J MGP_LPJ_G0025707
 protein coding gene Chr2:64502317-64625350 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025612
 protein coding gene Chr2:71064379-71200207 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026251
 protein coding gene Chr2:63919266-64044872 (-)
PWK/PhJ MGP_PWKPhJ_G0024713
 protein coding gene Chr2:61638598-61753474 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024520
 protein coding gene Chr2:64063988-64181180 (-)
WSB/EiJ MGP_WSBEiJ_G0025040
 protein coding gene Chr2:64277786-64395347 (-)



Homology
more
  • Human Ortholog
    GRB14, growth factor receptor bound protein 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRB14, growth factor receptor bound protein 14
  • Links
    NCBI Gene ID: 2888
    neXtProt AC: NX_Q14449
    UniProt: Q14449

  • Chr Location
    2q24.3; chr2:164492406-164621850 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in improved glucose tolerance, lower circulating insulin levels and increased incorporation of glucose into glycogen in the liver and skeletal muscle of males. Both males and females exhibit a decrease in body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    8
  • cDNA Data
    25
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50915 NCBI Gene Model | MGI Sequence Detail 110535 C57BL/6J ±  kb
    transcript NM_016719 RefSeq | MGI Sequence Detail 2003 C57BL/6  
    polypeptide Q9JLM9 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138995
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:200516 Jones N, et al., Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999 Oct 22;274(43):30896-905
    • Latest
      J:297953 Ding X, et al., Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction. Sci Rep. 2020 Feb 25;10(1):3417
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    05/24/2023
    MGI 6.22     		The Jackson Laboratory