Nrbf2 MGI Mouse Gene Detail - MGI:1354950 - nuclear receptor binding factor 2

Symbol

Nrbf2
Name

nuclear receptor binding factor 2

Feature Type

protein coding gene
IDs

MGI:1354950
NCBI Gene: 641340
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:67102463-67121076 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 34.89 cM
Mapping Data

1 experiment

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354950	protein coding gene	Chr10:67102463-67121084 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017323	protein coding gene	Chr10:67013669-67034181 (-)
A/J	MGP_AJ_G0017300	protein coding gene	Chr10:64778991-64797469 (-)
AKR/J	MGP_AKRJ_G0017261	protein coding gene	Chr10:66561748-66580374 (-)
BALB/cJ	MGP_BALBcJ_G0017260	protein coding gene	Chr10:64984980-65003640 (-)
C3H/HeJ	MGP_C3HHeJ_G0017084	protein coding gene	Chr10:66526248-66544823 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017718	protein coding gene	Chr10:69448299-69467139 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015408	protein coding gene	Chr10:61464090-61483705 (-)
CAST/EiJ	MGP_CASTEiJ_G0016654	protein coding gene	Chr10:66570898-66591278 (-)
CBA/J	MGP_CBAJ_G0017056	protein coding gene	Chr10:72087697-72106282 (-)
DBA/2J	MGP_DBA2J_G0017161	protein coding gene	Chr10:64159833-64178710 (-)
FVB/NJ	MGP_FVBNJ_G0017154	protein coding gene	Chr10:63331184-63349960 (-)
LP/J	MGP_LPJ_G0017234	protein coding gene	Chr10:67419842-67438358 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017182	protein coding gene	Chr10:74336076-74355599 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017757	protein coding gene	Chr10:66442146-66461788 (-)
PWK/PhJ	MGP_PWKPhJ_G0016438	protein coding gene	Chr10:63947995-63966908 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016220	protein coding gene	Chr10:65779939-65821116 (-)
WSB/EiJ	MGP_WSBEiJ_G0016718	protein coding gene	Chr10:66369941-66388843 (-)

Human Ortholog

NRBF2, nuclear receptor binding factor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRBF2, nuclear receptor binding factor 2
Synonyms

COPR, COPR1, COPR2, NRBF-2
Links

HGNC:19692

NCBI Gene ID: 29982

neXtProt AC: NX_Q96F24

UniProt: Q96F24
Chr Location

10q21.3; chr10:63133247-63155031 (+) GRCh38

Alliance of Genome Resources

Nrbf2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NRBF2
Gene Tree

Nrbf2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Nrbf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous null for this allele develop focal liver necrosis and ductular reaction in the liver and cells show impaired autophagosome maturation and increased susceptibility to ER stress.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

37

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NRBF2

Xenbase nrbf2

ZFIN nrbf2b

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Nrbf2 interacts with 236 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

51
RefSeq

8
UniProt

2
CCDS

CCDS23902.1

Ensembl

ENSMUSG00000075000 (Evidence)
NCBI Gene

641340

			Length	Strain/Species	Flank
genomic	641340	NCBI Gene Model \| MGI Sequence Detail	18614	C57BL/6J	± kb
transcript	NM_001402047	RefSeq \| MGI Sequence Detail	2972	C57BL/6
polypeptide	Q8VCQ3	UniProt \| EBI \| MGI Sequence Detail	287	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011417 nuclear receptor-binding factor 2

(term hierarchy)
PDB

2CRB
InterPro Domains

IPR039679 Nuclear receptor-binding factor 2

IPR015056 Nuclear receptor-binding factor 2, C-terminal

IPR033393 Nuclear receptor-binding factor 2, MIT domain

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All nucleic 37

cDNA 37

Microarray probesets 5

Summaries

All 38

Gene Ontology 6

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:324480 Wu MY, et al., PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation. Autophagy. 2021 May;17(5):1096-1111

TSS for Nrbf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97946	Chr10:67121027-67121095 (-)	15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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