Rgs11 MGI Mouse Gene Detail - MGI:1354739 - regulator of G-protein signaling 11

Symbol

Rgs11
Name

regulator of G-protein signaling 11

Feature Type

protein coding gene
IDs

MGI:1354739
NCBI Gene: 50782
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:26421925-26430298 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.07 cM
Mapping Data

3 experiments

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354739	protein coding gene	Chr17:26421500-26430298 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023395	protein coding gene	Chr17:25350124-25358393 (+)
A/J	MGP_AJ_G0023354	protein coding gene	Chr17:24594162-24603369 (+)
AKR/J	MGP_AKRJ_G0023320	protein coding gene	Chr17:24705213-24713541 (+)
BALB/cJ	MGP_BALBcJ_G0023359	protein coding gene	Chr17:24815438-24823792 (+)
C3H/HeJ	MGP_C3HHeJ_G0023119	protein coding gene	Chr17:25097452-25105734 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023801	protein coding gene	Chr17:26413771-26422321 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021277	protein coding gene	Chr17:22053171-22061563 (+)
CAST/EiJ	MGP_CASTEiJ_G0022621	protein coding gene	Chr17:25005225-25014295 (+)
CBA/J	MGP_CBAJ_G0023094	protein coding gene	Chr17:27349838-27361545 (+)
DBA/2J	MGP_DBA2J_G0023224	protein coding gene	Chr17:24187488-24195814 (+)
FVB/NJ	MGP_FVBNJ_G0023194	protein coding gene	Chr17:23949961-23958277 (+)
LP/J	MGP_LPJ_G0023301	protein coding gene	Chr17:25628781-25637080 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023213	protein coding gene	Chr17:26919874-26928037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023841	protein coding gene	Chr17:25055631-25063968 (+)
PWK/PhJ	MGP_PWKPhJ_G0022370	protein coding gene	Chr17:22957926-22966634 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022188	protein coding gene	Chr17:23122450-23130573 (+)
WSB/EiJ	MGP_WSBEiJ_G0022684	protein coding gene	Chr17:25077071-25085645 (+)

Human Ortholog

RGS11, regulator of G protein signaling 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS11, regulator of G protein signaling 11
Synonyms

RS11
Links

HGNC:9993

NCBI Gene ID: 8786

neXtProt AC: NX_O94810

UniProt: O94810
Chr Location

16p13.3; chr16:268301-275980 (-) GRCh38

MGI Vertebrate Homology

Rgs11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RGS11
Gene Tree

Rgs11

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
1 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Radiation induced

2
Targeted

2
Genomic Mutations

2 involving Rgs11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a null allele exhibit abnormal cone and rod b-wave electrophysiology.

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

34
cDNA Data

46
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

55
RefSeq

4
UniProt

4
CCDS

CCDS37511.1

Ensembl

ENSMUSG00000024186 (Evidence)
NCBI Gene

50782

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024186	Ensembl Gene Model \| MGI Sequence Detail	8374	C57BL/6J	± kb
transcript	ENSMUST00000025020	Ensembl \| MGI Sequence Detail	2006	Not Applicable
polypeptide	ENSMUSP00000025020	Ensembl \| MGI Sequence Detail	466	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013946 regulator of G-protein signaling 11

(term hierarchy)
InterPro Domains

IPR000591 DEP domain

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR047016 Regulator of G protein signaling 6/7/9/11

IPR047017 Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily

IPR040759 Regulator of G-protein signalling, DHEX domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 47

cDNA 46

Primer pair 1

Microarray probesets 3

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MGI:2147122

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 20
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:332184 Cao Y, et al., Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Curr Biol. 2022 Nov 21;32(22):4783-4796.e3

TSS for Rgs11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143215	Chr17:26421920-26421990 (+)	30 bp
Tssr143216	Chr17:26422789-26422800 (+)	870 bp
Tssr143217	Chr17:26423291-26423304 (+)	1,373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23