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Prok2 Gene Detail
Summary
  • Symbol
    Prok2
  • Name
    prokineticin 2
  • Synonyms
    Bombina variegata 8kDa protein, Bv8, PK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354178
    NCBI Gene: 50501
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:99688260-99703353 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 46.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354178
 protein coding gene Chr6:99687833-99703368 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031084
 protein coding gene Chr6:101677292-101694052 (-)
A/J MGP_AJ_G0031053
 protein coding gene Chr6:97799171-97814265 (-)
AKR/J MGP_AKRJ_G0030984
 protein coding gene Chr6:100474859-100489939 (-)
BALB/cJ MGP_BALBcJ_G0031064
 protein coding gene Chr6:97767479-97782576 (-)
C3H/HeJ MGP_C3HHeJ_G0030644
 protein coding gene Chr6:83913285-83928404 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031523
 protein coding gene Chr6:104239588-104254713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028687
 protein coding gene Chr6:95630998-95646371 (-)
CAST/EiJ MGP_CASTEiJ_G0030171
 protein coding gene Chr6:100711928-100726987 (-)
CBA/J MGP_CBAJ_G0030750
 protein coding gene Chr6:108234570-108251520 (-)
DBA/2J MGP_DBA2J_G0030903
 protein coding gene Chr6:96936735-96951867 (-)
FVB/NJ MGP_FVBNJ_G0030857
 protein coding gene Chr6:96106668-96121756 (-)
LP/J MGP_LPJ_G0030983
 protein coding gene Chr6:101719595-101735899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030891
 protein coding gene Chr6:112029952-112045043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031550
 protein coding gene Chr6:100395348-100410421 (-)
PWK/PhJ MGP_PWKPhJ_G0029887
 protein coding gene Chr6:95946527-95961678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029715
 protein coding gene Chr6:99286726-99301520 (-)
WSB/EiJ MGP_WSBEiJ_G0030255
 protein coding gene Chr6:100893447-100909322 (-)



Homology
more
  • Human Ortholog
    PROK2, prokineticin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROK2, prokineticin 2
  • Synonyms
    BV8, HH4, KAL4, MIT1, PK2
  • Links
    NCBI Gene ID: 60675
    neXtProt AC: NX_Q9HC23
    UniProt: Q9HC23

  • Chr Location
    3p13; chr3:71771655-71785206 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PROK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have a significantly reduced olfactory bulb displaying abnormal architecture and accumulation of neuronal progenitors in the rostral migratory stream.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    19
  • cDNA Data
    7
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030069 Ensembl Gene Model | MGI Sequence Detail 15094 C57BL/6J ±  kb
    transcript ENSMUST00000032152 Ensembl | MGI Sequence Detail 1423 Not Applicable  
    polypeptide ENSMUSP00000032152 Ensembl | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 2
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:58759 Wechselberger C, et al., The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett. 1999 Nov 26;462(1-2):177-81
    • Latest
      J:324615 Liu B, et al., Molecular and neural basis of pleasant touch sensation. Science. 2022 Apr 29;376(6592):483-491
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory