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Txnrd1 Gene Detail
Summary
  • Symbol
    Txnrd1
  • Name
    thioredoxin reductase 1
  • Synonyms
    TR, TR1, TR alpha, TrxR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354175
    NCBI Gene: 50493
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:82669785-82733546 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 40.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    560 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354175
 protein coding gene Chr10:82669785-82733558 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017581
 protein coding gene Chr10:83627917-83660620 (+)
A/J MGP_AJ_G0017561
 protein coding gene Chr10:80803603-80835367 (+)
AKR/J MGP_AKRJ_G0017520
 protein coding gene Chr10:83059273-83090142 (+)
BALB/cJ MGP_BALBcJ_G0017524
 protein coding gene Chr10:81065302-81104889 (+)
C3H/HeJ MGP_C3HHeJ_G0017346
 protein coding gene Chr10:83120348-83159324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017981
 protein coding gene Chr10:86542749-86582605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015666
 protein coding gene Chr10:76543239-76579909 (+)
CAST/EiJ MGP_CASTEiJ_G0016913
 protein coding gene Chr10:83039177-83071909 (+)
CBA/J MGP_CBAJ_G0017316
 protein coding gene Chr10:90114030-90152307 (+)
DBA/2J MGP_DBA2J_G0017422
 protein coding gene Chr10:79977118-80008369 (+)
FVB/NJ MGP_FVBNJ_G0017416
 protein coding gene Chr10:79202642-79241060 (+)
LP/J MGP_LPJ_G0017494
 protein coding gene Chr10:84263907-84305988 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017444
 protein coding gene Chr10:91782276-91821641 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018018
 protein coding gene Chr10:82975417-83014324 (+)
PWK/PhJ MGP_PWKPhJ_G0016694
 protein coding gene Chr10:79854151-79885583 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016484
 protein coding gene Chr10:81674081-81715795 (+)
WSB/EiJ MGP_WSBEiJ_G0016972
 protein coding gene Chr10:83009839-83051596 (+)



Homology
more
  • Human Ortholog
    TXNRD1, thioredoxin reductase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNRD1, thioredoxin reductase 1
  • Synonyms
    GRIM-12, TR, TR1, TRXR1, TXNR, TXNR1
  • Links
    NCBI Gene ID: 7296
    neXtProt AC: NX_Q16881
    UniProt: Q16881

  • Chr Location
    12q23.3; chr12:104215779-104350307 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TXNRD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit early embryonic lethality (by E10.5) and display severe growth retardation and fail to turn. Embryos also exhibit decreased cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1022
  • Tissues
    126
  • cDNA Data
    17
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020250 Ensembl Gene Model | MGI Sequence Detail 63762 C57BL/6J ±  kb
    transcript ENSMUST00000219368 Ensembl | MGI Sequence Detail 3622 Not Applicable  
    polypeptide ENSMUSP00000151629 Ensembl | MGI Sequence Detail 613 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016871 thioredoxin reductase 1, cytoplasmic
      (term hierarchy)
    • EC
      1.11.1.2, 1.8.1.9
    • InterPro Domains
      IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR046952 Glutathione reductase/thioredoxin reductase-like
      IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
      IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
      IPR006338 Thioredoxin/glutathione reductase selenoprotein
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 4

      Microarray probesets 5
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345099 Wang X, et al., Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory