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Usp21 Gene Detail
Summary
  • Symbol
    Usp21
  • Name
    ubiquitin specific peptidase 21
  • Synonyms
    ESTM28, Usp16, Usp23, W53272
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353665
    NCBI Gene: 30941
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171109523-171115534 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353665
 protein coding gene Chr1:171109519-171115564 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016753
 protein coding gene Chr1:177069134-177075178 (-)
A/J MGP_AJ_G0016733
 protein coding gene Chr1:169862781-169868847 (-)
AKR/J MGP_AKRJ_G0016699
 protein coding gene Chr1:174952928-174958974 (-)
BALB/cJ MGP_BALBcJ_G0016694
 protein coding gene Chr1:170350092-170359105 (-)
C3H/HeJ MGP_C3HHeJ_G0016517
 protein coding gene Chr1:175196031-175202072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017155
 protein coding gene Chr1:182955330-182961362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014863
 protein coding gene Chr1:161543934-161549915 (-)
CAST/EiJ MGP_CASTEiJ_G0016098
 protein coding gene Chr1:174826332-174832394 (-)
CBA/J MGP_CBAJ_G0016492
 protein coding gene Chr1:189467947-189473999 (-)
DBA/2J MGP_DBA2J_G0016599
 protein coding gene Chr1:168703047-168709094 (-)
FVB/NJ MGP_FVBNJ_G0016595
 protein coding gene Chr1:167050527-167056576 (-)
LP/J MGP_LPJ_G0016670
 protein coding gene Chr1:178188700-178194753 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016622
 protein coding gene Chr1:196751484-196757523 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017192
 protein coding gene Chr1:174821672-174828115 (-)
PWK/PhJ MGP_PWKPhJ_G0015884
 protein coding gene Chr1:167925491-167933588 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015668
 protein coding gene Chr1:173606202-173613176 (-)
WSB/EiJ MGP_WSBEiJ_G0016160
 protein coding gene Chr1:174938355-174944399 (-)



Homology
more
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP21, ubiquitin specific peptidase 21
  • Synonyms
    USP16, USP23
  • Links
    NCBI Gene ID: 27005
    neXtProt AC: NX_Q9UK80
    UniProt: Q9UK80

  • Chr Location
    1q23.3; chr1:161159450-161165723 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and fertile but develop splenomegaly, show an increased percentage of macrophages and neutrophils in spleen, and are more resistant to vesicular stomatitis virus (VSV) infection with elevated interferon production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    4
  • cDNA Data
    76
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30941 NCBI Gene Model | MGI Sequence Detail 6012 C57BL/6J ±  kb
    transcript NM_013919 RefSeq | MGI Sequence Detail 2200 ZRU/MplStud  
    polypeptide Q9QZL6 UniProt | EBI | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 2
      cDNA 76
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1334424
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:332127 Montauti E, et al., A deubiquitination module essential for T(reg) fitness in the tumor microenvironment. Sci Adv. 2022 Nov 25;8(47):eabo4116
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory