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Usp25 Gene Detail
Summary
  • Symbol
    Usp25
  • Name
    ubiquitin specific peptidase 25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353655
    NCBI Gene: 30940
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:76810594-76913668 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 44.40 cM, cytoband C3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3276 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353655
 protein coding gene Chr16:76810573-76913671 (+)
129S1/SvImJ ENSMUSG00200015637
 protein coding gene Chr16:73684233-73789544 (+)
A/J ENSMUSG00195022024
 protein coding gene Chr16:73477758-73580836 (+)
AKR/J ENSMUSG00220017459
 protein coding gene Chr16:73649470-73752569 (+)
BALB/cJ ENSMUSG00180001998
 protein coding gene Chr16:73549779-73652859 (+)
C3H/HeJ ENSMUSG00175008832
 protein coding gene Chr16:73832920-73936024 (+)
C57BL/6NJ ENSMUSG00215001613
 protein coding gene Chr16:73669188-73772276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020878
 protein coding gene Chr16:72192616-72300870 (+)
CAST/EiJ ENSTCUG00005007179
 protein coding gene Chr16:73497642-73603605 (+)
CBA/J ENSMUSG00210019519
 protein coding gene Chr16:73777998-73881085 (+)
DBA/2J ENSMUSG00185005073
 protein coding gene Chr16:73712500-73815561 (+)
FVB/NJ ENSMUSG00205013828
 protein coding gene Chr16:73565459-73668546 (+)
JF1/MsJ ENSUMUG00000011675
 protein coding gene Chr16:73859131-73964704 (+)
LP/J ENSMUSG00230018852
 protein coding gene Chr16:76281388-76386689 (+)
NOD/ShiLtJ ENSMUSG00190010839
 protein coding gene Chr16:73704178-73807269 (+)
NZO/HlLtJ ENSMUSG00225029374
 protein coding gene Chr16:79488827-79591959 (+)
PWK/PhJ ENSLUMG00010004942
 protein coding gene Chr16:73514468-73620514 (+)
SPRET/EiJ ENSMSPG00010014842
 protein coding gene Chr16:74356570-74463809 (+)
WSB/EiJ ENSIUOG00005016921
 protein coding gene Chr16:73695563-73800792 (+)



Homology
more
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP25, ubiquitin specific peptidase 25
  • Synonyms
    EIG19, USP21
  • Links
    NCBI Gene ID: 29761
    UniProt: Q9UHP3

  • Chr Location
    21q21.1; chr21:15729925-15880064 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    116
  • cDNA Data
    15
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022867 Ensembl Gene Model | MGI Sequence Detail 103075 C57BL/6J ±  kb
    transcript ENSMUST00000239066 Ensembl | MGI Sequence Detail 4986 Not Applicable  
    polypeptide ENSMUSP00000159060 Ensembl | MGI Sequence Detail 1125 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000017163 ubiquitin carboxyl-terminal hydrolase 25
      (term hierarchy)
    • PDB
      1VDL
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR054109 UBA-like domain
      IPR009060 UBA-like superfamily
      IPR044635 Ubiquitin carboxyl-terminal hydrolase 14-like
      IPR054108 Ubiquitin carboxyl-terminal hydrolase 25/28, UIM
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR003903 Ubiquitin interacting motif
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    • GlyGen
      P57080 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:60249 Valero R, et al., USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405
    • Latest
      J:385752 Li L, et al., USP25 aggravates liver cancer development and impairs chemosensitivity by limiting LATS1 activation. EMBO Rep. 2026 May;27(9):2406-2433
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory