Cbx8 MGI Mouse Gene Detail - MGI:1353589

Symbol

Cbx8
Name

chromobox 8
Synonyms

Pc3, polycomb 3

Feature Type

protein coding gene
IDs

MGI:1353589
NCBI Gene: 30951
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:118929262-118931739 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.33 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

88 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353589	protein coding gene	Chr11:118927131-118931795 (-)
129S1/SvImJ	ENSMUSG00200049628	protein coding gene	Chr11:116294893-116299557 (-)
A/J	ENSMUSG00195029278	protein coding gene	Chr11:115969820-115974484 (-)
AKR/J	ENSMUSG00220024151	protein coding gene	Chr11:116120209-116124873 (-)
BALB/cJ	ENSMUSG00180049306	protein coding gene	Chr11:116263792-116268459 (-)
C3H/HeJ	ENSMUSG00175032618	protein coding gene	Chr11:116221263-116225927 (-)
C57BL/6NJ	ENSMUSG00215045894	protein coding gene	Chr11:115790428-115795092 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017490	protein coding gene	Chr11:114927870-114932548 (-)
CAST/EiJ	ENSTCUG00005032813	protein coding gene	Chr11:115647059-115651724 (-)
CBA/J	ENSMUSG00210047905	protein coding gene	Chr11:115935358-115940022 (-)
DBA/2J	ENSMUSG00185021984	protein coding gene	Chr11:116248443-116253107 (-)
FVB/NJ	ENSMUSG00205023317	protein coding gene	Chr11:116096511-116101175 (-)
JF1/MsJ	ENSUMUG00000043808	protein coding gene	Chr11:116540430-116545090 (-)
LP/J	ENSMUSG00230050222	protein coding gene	Chr11:117314312-117318976 (-)
NOD/ShiLtJ	ENSMUSG00190031500	protein coding gene	Chr11:116318867-116323531 (-)
NZO/HlLtJ	ENSMUSG00225053183	protein coding gene	Chr11:119462525-119467189 (-)
PWK/PhJ	ENSLUMG00010019825	protein coding gene	Chr11:116052160-116056817 (-)
SPRET/EiJ	ENSMSPG00010041788	protein coding gene	Chr11:116626736-116631363 (-)
WSB/EiJ	ENSIUOG00005042917	protein coding gene	Chr11:116055288-116059952 (-)

Human Ortholog

CBX8, chromobox 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBX8, chromobox 8
Synonyms

PC3, RC1
Links

HGNC:15962

NCBI Gene ID: 57332

UniProt: Q9HC52
Chr Location

17q25.3; chr17:79792132-79801683 (-) GRCh38

MGI Vertebrate Homology

Cbx8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CBX8
Gene Tree

Cbx8

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired MLL-AF9 transformation but are otherwise viable with normal hematopoiesis.

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All GO Annotations

44
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

111
cDNA Data

26
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CBX8

Xenbase cbx8

ZFIN cbx8a, cbx8b

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS25709.1

Ensembl

ENSMUSG00000025578 (Evidence)
NCBI Gene

30951

			Length	Strain/Species	Flank
genomic	30951	NCBI Gene Model \| MGI Sequence Detail	2478	C57BL/6J	± kb
transcript	NM_013926	RefSeq \| MGI Sequence Detail	1413	Not Specified
polypeptide	Q9QXV1	UniProt \| EBI \| MGI Sequence Detail	362	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005089 chromobox protein homolog 8

(term hierarchy)
PDB

2DNV
InterPro Domains

IPR033773 CBX family C-terminal motif

IPR000953 Chromo/chromo shadow domain

IPR023780 Chromo domain

IPR023779 Chromo domain, conserved site

IPR016197 Chromo-like domain superfamily

IPR052458 Polycomb group PRC1-like complex component

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All nucleic 28

Genomic 1

cDNA 27

Microarray probesets 3

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 8
Earliest

J:60239 Hemenway CS, et al., Identification and analysis of a third mouse Polycomb gene, MPc3. Gene. 2000 Jan 25;242(1-2):31-40
Latest

J:382998 Li T, et al., CBX8 suppresses autophagy-dependent senescence in colorectal cancer by modulating the mTOR signaling pathway. Int J Biol Sci. 2026;22(6):3127-3143

TSS for Cbx8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112203	Chr11:118931731-118931763 (-)	-8 bp
Tssr112202	Chr11:118931709-118931729 (-)	20 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24