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Slc39a1 Gene Detail
Summary
  • Symbol
    Slc39a1
  • Name
    solute carrier family 39 (zinc transporter), member 1
  • Synonyms
    zip1, Zirtl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353474
    NCBI Gene: 30791
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90155512-90160923 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353474
protein coding gene Chr3:90155479-90160923 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0027387
protein coding gene Chr3:89680703-89685611 (+)
BALB/cJ MGP_BALBcJ_G0025529
protein coding gene Chr2:27361935-27371227 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0025974
protein coding gene Chr2:29301450-29309189 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025230
protein coding gene Chr3:83028983-83034077 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0027148
protein coding gene Chr3:97186651-97191870 (+)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027274
protein coding gene Chr3:103383272-103391659 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026173
protein coding gene Chr3:88606740-88611349 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SLC39A1, solute carrier family 39 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC39A1, solute carrier family 39 member 1
  • Synonyms
    ZIP1, ZIRTL
  • Links
    NCBI Gene ID: 27173
    neXtProt AC: NX_Q9NY26
    UniProt: Q9NY26

  • Chr Location
    1q21.3; chr1:153959099-153968184 (-)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
On a zinc-adequate diet, homozygous null mutant mice exhibit normal fertility and normal embryonic and postnatal development. E14 embryos of dams fed a zinc-deficient diet from day E8 have <3.3-fold the incidence of abnormalities seen in wild-type embryos of zinc-deprived wild-type mothers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30791 NCBI Gene Model | MGI Sequence Detail 5412 C57BL/6J ±  kb
    transcript NM_001411505 RefSeq | MGI Sequence Detail 2349 C57BL/6  
    polypeptide Q9QZ03 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 41
      Primer pair 4
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:39118 Crozet F, et al., Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. 1997 Mar 1;40(2):332-41
    • Latest
      J:337461 Elgheznawy A, et al., Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Front Immunol. 2023;14:1197894

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory