Airn Gene Detail

Summary

• Symbol
  Airn
• Name
  antisense Igf2r RNA
• Synonyms
  2810051F02Rik, 2810434M15Rik, Air, B930018I07Rik, D17Ertd663e

• Feature Type
  antisense lncRNA gene
  BioType Conflict
  
• IDs
  MGI:1353471
  NCBI Gene: 104103
• Alliance
  genome feature page
• Transcription Start Sites
  33 TSS

Location &
Maps

• Sequence Map
  Chr17:12960198-13078771 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 8.66 cM
• Mapping Data
  7 experiments

Strain
Comparison

• SNPs within 2kb
  612 from dbSNP Build 142
• Strain Annotations
  28

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353471	antisense lncRNA gene	Chr17:12960198-13079299 (+)
129S1/SvImJ	ENSMUSG00200034989	lncRNA gene	Chr17:9185608-9310637 (+)
129S1/SvImJ	ENSMUSG00200030759	protein coding gene	Chr17:9185671-9281087 (+)
A/J	ENSMUSG00195023778	lncRNA gene	Chr17:9384915-9509964 (+)
A/J	ENSMUSG00195021819	protein coding gene	Chr17:9464485-9480410 (+)
AKR/J	ENSMUSG00220026253	protein coding gene	Chr17:9533248-9549174 (+)
AKR/J	ENSMUSG00220027525	lncRNA gene	Chr17:9451068-9578743 (+)
BALB/cJ	ENSMUSG00180028333	lncRNA gene	Chr17:9034130-9159176 (+)
BALB/cJ	ENSMUSG00180024314	protein coding gene	Chr17:9034193-9129618 (+)
C3H/HeJ	ENSMUSG00175035397	lncRNA gene	Chr17:9178229-9298610 (+)
C57BL/6NJ	ENSMUSG00215029603	lncRNA gene	Chr17:9229521-9348380 (+)
C57BL/6NJ	ENSMUSG00215019678	protein coding gene	Chr17:9302897-9318824 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002991	antisense lncRNA gene	Chr17:4091146-4210110 (-)
CAST/EiJ	ENSTCUG00005022804	lncRNA gene	Chr17:9429286-9548291 (+)
CBA/J	ENSMUSG00210041596	lncRNA gene	Chr17:8841493-8961883 (+)
DBA/2J	ENSMUSG00185021967	protein coding gene	Chr17:9934536-10029964 (+)
DBA/2J	ENSMUSG00185023840	lncRNA gene	Chr17:9934473-10059513 (+)
FVB/NJ	ENSMUSG00205008646	protein coding gene	Chr17:9268616-9357839 (+)
FVB/NJ	ENSMUSG00205009883	lncRNA gene	Chr17:9268553-9387395 (+)
JF1/MsJ	ENSUMUG00000038996	lncRNA gene	Chr17:9531417-9657338 (+)
LP/J	ENSMUSG00230024174	protein coding gene	Chr17:11448807-11464736 (+)
LP/J	ENSMUSG00230027463	lncRNA gene	Chr17:11369257-11494288 (+)
NOD/ShiLtJ	ENSMUSG00190036951	lncRNA gene	Chr17:9373977-9493523 (+)
NZO/HlLtJ	ENSMUSG00225049062	lncRNA gene	Chr17:13288151-13413178 (+)
NZO/HlLtJ	ENSMUSG00225047525	protein coding gene	Chr17:13288214-13383621 (+)
PWK/PhJ	ENSLUMG00010019424	lncRNA gene	Chr17:9360367-9479322 (+)
SPRET/EiJ	ENSMSPG00010038453	lncRNA gene	Chr17:4126481-4247402 (-)
WSB/EiJ	ENSIUOG00005014386	lncRNA gene	Chr17:9266697-9385506 (+)

Homology

• Human Ortholog
  AIRN, antisense of IGF2R non-protein coding RNA

• Vertebrate Orthologs
  1

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  AIRN, antisense of IGF2R non-protein coding RNA
  
• Synonyms
  AIR, IGF2R-AS, IGF2RAS, IGF2R-AS1, NCRNA00088
• Links
  HGNC:34515

  NCBI Gene ID: 100271873

  
  
• Chr Location
  6q25.3; chr6:160002409-160007664 (-)  GRCh38

---

• MGI Vertebrate Homology
  Airn stringent orthology
  1 human;1 mouse
  
• HCOP
  vertebrate homology predictions: AIRN
• Gene Tree
  Airn
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 2 alleles in 2 genetic backgrounds
  7 phenotype references
  

• All Mutations and Alleles
  7
• Gene trapped
  2
• Targeted
  5
• Genomic Mutations
  3 involving Airn
• Find Mice (IMSR)
  5 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Whereas heterozygous mice carrying a maternally inherited allele showed no overt phenotype, heterozygous mice carrying a paternally inherited allele and homozygous mice exhibited reduced body weight at birth.

Expression

• Assay Results
  722
• Tissues
  21
• cDNA Data
  25
• Literature Summary
  14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  92
• RefSeq
  4
• UniProt
  1

• Ensembl
  ENSMUSG00000078247 (Evidence)
• NCBI Gene
  104103

Representative Sequences			Length	Strain/Species
genomic	104103	NCBI Gene Model | MGI Sequence Detail	118574	C57BL/6J
transcript	NR_027784	RefSeq | MGI Sequence Detail	1399	ZRU/MplStud
polypeptide	Q78TB4	UniProt | EBI | MGI Sequence Detail	109	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 40

  Genomic 1

  cDNA 27

  Primer pair 12

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1289299, MGI:1917228, MGI:1919954, MGI:2146811, MGI:2146894, MGI:2147040, MGI:2443603

References

• Summaries
  All 51

  Developmental Gene Expression 14

  Phenotypes 7
• Earliest
  J:43503 Wutz A, et al., Imprinted expression of the Igf2r gene depends on an intronic CpG island [see comments]. Nature. 1997 Oct 16;389(6652):745-9
• Latest
  J:364540 Trotman JB, et al., Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs. Mol Cell. 2025 Mar 20;85(6):1117-1133.e14

TSS for Airn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142624	Chr17:12960226-12960237 (+)	34 bp
Tssr142625	Chr17:12960247-12960271 (+)	61 bp
Tssr142626	Chr17:12960272-12960286 (+)	81 bp
Tssr142627	Chr17:12963579-12963587 (+)	3,385 bp
Tssr142628	Chr17:12964738-12964774 (+)	4,558 bp
Tssr142629	Chr17:12965375-12965387 (+)	5,183 bp
Tssr142630	Chr17:12965418-12965430 (+)	5,226 bp
Tssr142631	Chr17:12965558-12965571 (+)	5,367 bp
Tssr142632	Chr17:12967262-12967266 (+)	7,066 bp
Tssr142633	Chr17:12973700-12973714 (+)	13,509 bp
Tssr142634	Chr17:12974321-12974343 (+)	14,134 bp
Tssr142635	Chr17:12974905-12974919 (+)	14,714 bp
Tssr142636	Chr17:12978076-12978088 (+)	17,884 bp
Tssr142637	Chr17:12979065-12979070 (+)	18,870 bp
Tssr142638	Chr17:12981816-12981822 (+)	21,621 bp
Tssr142639	Chr17:12984236-12984262 (+)	24,051 bp
Tssr142642	Chr17:13007198-13007213 (+)	47,008 bp
Tssr142643	Chr17:13008062-13008073 (+)	47,870 bp
Tssr142644	Chr17:13009980-13009984 (+)	49,784 bp
Tssr142645	Chr17:13011772-13011793 (+)	51,585 bp
Tssr142646	Chr17:13012228-13012231 (+)	52,032 bp
Tssr142647	Chr17:13012822-13012825 (+)	52,626 bp
Tssr142648	Chr17:13017482-13017496 (+)	57,291 bp
Tssr142649	Chr17:13017861-13017891 (+)	57,678 bp
Tssr142650	Chr17:13018031-13018049 (+)	57,842 bp
Tssr142651	Chr17:13024514-13024539 (+)	64,329 bp
Tssr142652	Chr17:13025002-13025034 (+)	64,820 bp
Tssr142653	Chr17:13026053-13026091 (+)	65,874 bp
Tssr142654	Chr17:13029429-13029451 (+)	69,242 bp
Tssr142655	Chr17:13040424-13040442 (+)	80,235 bp
Tssr142656	Chr17:13040972-13040975 (+)	80,776 bp
Tssr142657	Chr17:13042290-13042304 (+)	82,099 bp
Tssr142658	Chr17:13077947-13077956 (+)	117,754 bp