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Fbxw2 Gene Detail
Summary
  • Symbol
    Fbxw2
  • Name
    F-box and WD-40 domain protein 2
  • Synonyms
    FBW2, Fwd2, MD6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353435
    NCBI Gene: 30050
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34694526-34716323 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    500 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353435
 protein coding gene Chr2:34694185-34716323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025642
 protein coding gene Chr2:33413188-33434792 (-)
A/J MGP_AJ_G0025619
 protein coding gene Chr2:31993014-32014798 (-)
AKR/J MGP_AKRJ_G0025589
 protein coding gene Chr2:33124123-33145856 (-)
BALB/cJ MGP_BALBcJ_G0025616
 protein coding gene Chr2:32103280-32125009 (-)
C3H/HeJ MGP_C3HHeJ_G0025376
 protein coding gene Chr2:33014862-33037338 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026060
 protein coding gene Chr2:34381987-34404512 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023469
 protein coding gene Chr2:30691604-30714280 (-)
CAST/EiJ MGP_CASTEiJ_G0024838
 protein coding gene Chr2:33010296-33033509 (-)
CBA/J MGP_CBAJ_G0025354
 protein coding gene Chr2:35711733-35735279 (-)
DBA/2J MGP_DBA2J_G0025487
 protein coding gene Chr2:31765272-31786789 (-)
FVB/NJ MGP_FVBNJ_G0025449
 protein coding gene Chr2:31658230-31679785 (-)
LP/J MGP_LPJ_G0025573
 protein coding gene Chr2:33330575-33353978 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025480
 protein coding gene Chr2:35229530-35252264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026118
 protein coding gene Chr2:33012064-33035372 (-)
PWK/PhJ MGP_PWKPhJ_G0024586
 protein coding gene Chr2:31679557-31703206 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024386
 protein coding gene Chr2:33172175-33195365 (-)
WSB/EiJ MGP_WSBEiJ_G0024907
 protein coding gene Chr2:33188788-33214258 (-)



Homology
more
  • Human Ortholog
    FBXW2, F-box and WD repeat domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXW2, F-box and WD repeat domain containing 2
  • Synonyms
    FBW2, Fwd2, Md6
  • Links
    NCBI Gene ID: 26190
    UniProt: Q9UKT8

  • Chr Location
    9q33.2; chr9:120751978-120793416 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    33
  • cDNA Data
    17
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035949 Ensembl Gene Model | MGI Sequence Detail 21798 C57BL/6J ±  kb
transcript ENSMUST00000113078 Ensembl | MGI Sequence Detail 1872 Not Applicable  
polypeptide ENSMUSP00000108701 Ensembl | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 10
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:53625 Duff K, et al., Secondary structure analysis identifies a putative mouse protein demonstrating similarity to the repeat units found in CDC4, the G protein beta subunits and related proteins. DNA Seq. 1992;3(4):213-20
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/09/2025
MGI 6.24 		The Jackson Laboratory