About   Help   FAQ
Stau2 Gene Detail
Summary
  • Symbol
    Stau2
  • Name
    staufen double-stranded RNA binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352508
    NCBI Gene: 29819
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:16298898-16590336 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 5.05 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352508
protein coding gene Chr1:16298898-16591228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015855
protein coding gene Chr1:13709096-14024395 (-)
A/J MGP_AJ_G0015836
protein coding gene Chr1:13547946-13850363 (-)
AKR/J MGP_AKRJ_G0015795
protein coding gene Chr1:13583318-13864226 (-)
BALB/cJ MGP_BALBcJ_G0015792
protein coding gene Chr1:13274192-13584322 (-)
C3H/HeJ MGP_C3HHeJ_G0015626
protein coding gene Chr1:13579964-13899799 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016246
protein coding gene Chr1:14319461-14637603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013967
protein coding gene Chr1:12168514-12461003 (-)
CAST/EiJ MGP_CASTEiJ_G0015207
protein coding gene Chr1:13672933-13971833 (-)
CBA/J MGP_CBAJ_G0015599
protein coding gene Chr1:14656750-14979719 (-)
DBA/2J MGP_DBA2J_G0015698
protein coding gene Chr1:13146369-13458336 (-)
FVB/NJ MGP_FVBNJ_G0015703
protein coding gene Chr1:12964383-13248512 (-)
LP/J MGP_LPJ_G0015770
protein coding gene Chr1:13913270-14229172 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015722
protein coding gene Chr1:15293238-15602688 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016293
protein coding gene Chr1:13540595-13831545 (-)
PWK/PhJ MGP_PWKPhJ_G0014991
protein coding gene Chr1:12948372-13229720 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014772
protein coding gene Chr1:13713353-14024364 (-)
WSB/EiJ MGP_WSBEiJ_G0015270
protein coding gene Chr1:13473466-13767007 (-)



Homology
more
  • Human Ortholog
    STAU2, staufen double-stranded RNA binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAU2, staufen double-stranded RNA binding protein 2
  • Synonyms
    39K2, 39K3
  • Links
    NCBI Gene ID: 27067
    neXtProt AC: NX_Q9NUL3
    UniProt: Q9NUL3

  • Chr Location
    8q21.11; chr8:73420369-73747708 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a hypomorphic gene trap allele show impaired motor coordination but increased motor learning capacity in the rotarod test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025920 Ensembl Gene Model | MGI Sequence Detail 291439 C57BL/6J ±  kb
    transcript ENSMUST00000162751 Ensembl | MGI Sequence Detail 3030 Not Applicable  
    polypeptide ENSMUSP00000124505 Ensembl | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015727 double-stranded RNA-binding protein Staufen homolog 2
    • PDB
    • InterPro Domains
      IPR014720 Double-stranded RNA-binding domain
      IPR051740 Double-stranded RNA-binding domain-containing protein
      IPR044474 Staufen 2, fourth double-stranded RNA binding domain
      IPR044464 Staufen 2, second double-stranded RNA binding domain
      IPR044473 Staufen 2, third double-stranded RNA binding domain
      IPR032478 Staufen, C-terminal
    • GlyGen
      Q8CJ67 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 60
      Primer pair 4

      Microarray probesets 7
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:58925 Buchner G, et al., Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. Genomics. 1999 Nov 15;62(1):113-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    10/29/2024
    MGI 6.24
    The Jackson Laboratory