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Ndrg3 Gene Detail
Summary
  • Symbol
    Ndrg3
  • Name
    N-myc downstream regulated gene 3
  • Synonyms
    4833415O14Rik, Ndr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352499
    NCBI Gene: 29812
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156769265-156833976 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352499
 protein coding gene Chr2:156769262-156834052 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026772
 protein coding gene Chr2:161878479-161959883 (-)
A/J MGP_AJ_G0026738
 protein coding gene Chr2:155422147-155489951 (-)
AKR/J MGP_AKRJ_G0026709
 protein coding gene Chr2:159967623-160055841 (-)
BALB/cJ MGP_BALBcJ_G0026747
 protein coding gene Chr2:155705889-155773484 (-)
C3H/HeJ MGP_C3HHeJ_G0026489
 protein coding gene Chr2:160292392-160363711 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027196
 protein coding gene Chr2:166572933-166728454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024566
 protein coding gene Chr2:148876925-148941670 (-)
CAST/EiJ MGP_CASTEiJ_G0025951
 protein coding gene Chr2:160634041-160804732 (-)
CBA/J MGP_CBAJ_G0026466
 protein coding gene Chr2:172688535-172776712 (-)
DBA/2J MGP_DBA2J_G0026604
 protein coding gene Chr2:154592818-154659299 (-)
FVB/NJ MGP_FVBNJ_G0026571
 protein coding gene Chr2:152976145-153051814 (-)
LP/J MGP_LPJ_G0026709
 protein coding gene Chr2:161959127-162056142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026592
 protein coding gene Chr2:176552284-176628410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027252
 protein coding gene Chr2:159801822-159878909 (-)
PWK/PhJ MGP_PWKPhJ_G0025685
 protein coding gene Chr2:154100309-154169496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025488
 protein coding gene Chr2:158740413-158819682 (-)
WSB/EiJ MGP_WSBEiJ_G0026021
 protein coding gene Chr2:160688473-160760222 (-)



Homology
more
  • Human Ortholog
    NDRG3, NDRG family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDRG3, NDRG family member 3
  • Links
    NCBI Gene ID: 57446
    neXtProt AC: NX_Q9UGV2
    UniProt: Q9UGV2

  • Chr Location
    20q11.23; chr20:36651766-36746090 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality before weaning. Mice heterozygous for another null allele exhibit reduced male fertility due to impaired double strand break repair in spermatocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
DNA-templated transcription
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    79
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027634 Ensembl Gene Model | MGI Sequence Detail 64712 C57BL/6J ±  kb
    transcript ENSMUST00000069600 Ensembl | MGI Sequence Detail 2612 Not Applicable  
    polypeptide ENSMUSP00000070052 Ensembl | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139046, MGI:2442824
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:58924 Okuda T, et al., Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15
    • Latest
      J:330551 Sohn HA, et al., Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers. Cells. 2022 May 4;11(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/21/2023
    MGI 6.22     		The Jackson Laboratory