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Ndrg2 Gene Detail
Summary
  • Symbol
    Ndrg2
  • Name
    N-myc downstream regulated gene 2
  • Synonyms
    Ndr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352498
    NCBI Gene: 29811
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52142728-52151461 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352498
 protein coding gene Chr14:52142728-52151615 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021283
 protein coding gene Chr14:45927698-45935924 (-)
A/J MGP_AJ_G0021240
 protein coding gene Chr14:44733058-44741284 (-)
AKR/J MGP_AKRJ_G0021216
 protein coding gene Chr14:46349352-46357580 (-)
BALB/cJ MGP_BALBcJ_G0021244
 protein coding gene Chr14:44840963-44849189 (-)
C3H/HeJ MGP_C3HHeJ_G0021024
 protein coding gene Chr14:46155240-46164038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021683
 protein coding gene Chr14:47940024-47948199 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019228
 protein coding gene Chr14:43923890-43932174 (-)
CAST/EiJ MGP_CASTEiJ_G0020543
 protein coding gene Chr14:43119002-43127767 (-)
CBA/J MGP_CBAJ_G0020991
 protein coding gene Chr14:49410818-49419046 (-)
DBA/2J MGP_DBA2J_G0021112
 protein coding gene Chr14:44497955-44506189 (-)
FVB/NJ MGP_FVBNJ_G0021095
 protein coding gene Chr14:44080083-44088316 (-)
LP/J MGP_LPJ_G0021187
 protein coding gene Chr14:46528291-46536519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021118
 protein coding gene Chr14:48853121-48861354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021710
 protein coding gene Chr14:45736847-45745073 (-)
PWK/PhJ MGP_PWKPhJ_G0020292
 protein coding gene Chr14:41244366-41253189 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020119
 protein coding gene Chr14:41761947-41770199 (-)
WSB/EiJ MGP_WSBEiJ_G0020596
 protein coding gene Chr14:46035619-46044408 (-)



Homology
more
  • Human Ortholog
    NDRG2, NDRG family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDRG2, NDRG family member 2
  • Synonyms
    SYLD
  • Links
    NCBI Gene ID: 57447
    neXtProt AC: NX_Q9UN36
    UniProt: Q9UN36

  • Chr Location
    14q11.2; chr14:21016763-21070872 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop various types of tumors, including T-cell lymphomas, and have a shorter lifespan. Homozygotes for a second null allele show vertebral transformations. Homozygotes for a third null allele show reduced astrogliosis and inflammatory response after brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1457
  • Tissues
    427
  • cDNA Data
    224
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29811 NCBI Gene Model | MGI Sequence Detail 8734 C57BL/6J ±  kb
    transcript NM_001360268 RefSeq | MGI Sequence Detail 2304 C57BL/6  
    polypeptide Q9QYG0 UniProt | EBI | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 234
      cDNA 224
      Primer pair 9
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145602, MGI:2145752
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 19
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:58924 Okuda T, et al., Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15
    • Latest
      J:332634 Xu J, et al., Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions. J Neuroinflammation. 2022 Dec 26;19(1):314
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    05/24/2023
    MGI 6.22     		The Jackson Laboratory