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Prmt5 Gene Detail
Summary
  • Symbol
    Prmt5
  • Name
    protein arginine N-methyltransferase 5
  • Synonyms
    Jak-binding protein 1, Jbp1, Skb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351645
    NCBI Gene: 27374
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54744639-54754927 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.82 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351645
protein coding gene Chr14:54744639-54754982 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021312
protein coding gene Chr14:48462096-48472989 (-)
A/J MGP_AJ_G0021271
protein coding gene Chr14:47521792-47532143 (-)
AKR/J MGP_AKRJ_G0021247
protein coding gene Chr14:49235366-49245712 (-)
BALB/cJ MGP_BALBcJ_G0021275
protein coding gene Chr14:47490488-47501769 (-)
C3H/HeJ MGP_C3HHeJ_G0021055
protein coding gene Chr14:48932518-48943033 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021714
protein coding gene Chr14:50914857-50927172 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019258
protein coding gene Chr14:45939908-45949943 (-)
CAST/EiJ MGP_CASTEiJ_G0020574
protein coding gene Chr14:45173493-45185095 (-)
CBA/J MGP_CBAJ_G0021022
protein coding gene Chr14:52437465-52447787 (-)
DBA/2J MGP_DBA2J_G0021143
protein coding gene Chr14:47263536-47275595 (-)
FVB/NJ MGP_FVBNJ_G0021125
protein coding gene Chr14:46719375-46729726 (-)
LP/J MGP_LPJ_G0021217
protein coding gene Chr14:49473063-49485205 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021149
protein coding gene Chr14:51865432-51876754 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021740
protein coding gene Chr14:48423263-48434449 (-)
PWK/PhJ MGP_PWKPhJ_G0020320
protein coding gene Chr14:43793637-43804112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020148
protein coding gene Chr14:44405920-44416133 (-)
WSB/EiJ MGP_WSBEiJ_G0020627
protein coding gene Chr14:48720543-48731768 (-)



Homology
more
  • Human Ortholog
    PRMT5, protein arginine methyltransferase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRMT5, protein arginine methyltransferase 5
  • Synonyms
    HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs
  • Links
    NCBI Gene ID: 10419
    neXtProt AC: NX_O14744
    UniProt: O14744

  • Chr Location
    14q11.2; chr14:22920525-22929408 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Prmt5 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 5 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality before somite formation with failure of inner cell mass proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27374 NCBI Gene Model | MGI Sequence Detail 10289 C57BL/6J ±  kb
    transcript NM_001313906 RefSeq | MGI Sequence Detail 2720 ZRU/MplStud  
    polypeptide Q8CIG8 UniProt | EBI | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      cDNA 208

      Microarray probesets 2
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 16
      Phenotypes 50
    • Earliest
      J:58151 Pollack BP, et al., The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999 Oct 29;274(44):31531-42
    • Latest
      J:347432 Katanasaka Y, et al., Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice. Nat Commun. 2024 Mar 19;15(1):2472

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory