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Tnfrsf12a Gene Detail
Summary
  • Symbol
    Tnfrsf12a
  • Name
    tumor necrosis factor receptor superfamily, member 12a
  • Synonyms
    Fn14, TweakR, TWEAK-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351484
    NCBI Gene: 27279
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23894419-23896423 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 11.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351484
protein coding gene Chr17:23894419-23896442 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023263
protein coding gene Chr17:22590822-22592822 (-)
A/J MGP_AJ_G0023223
protein coding gene Chr17:21941077-21943077 (-)
AKR/J MGP_AKRJ_G0023193
protein coding gene Chr17:22017415-22019417 (-)
BALB/cJ MGP_BALBcJ_G0023228
protein coding gene Chr17:22155509-22157510 (-)
C3H/HeJ MGP_C3HHeJ_G0022988
protein coding gene Chr17:22378919-22380920 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023671
protein coding gene Chr17:23572320-23574322 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021152
protein coding gene Chr17:19510113-19512118 (-)
CAST/EiJ MGP_CASTEiJ_G0022494
protein coding gene Chr17:22211770-22213769 (-)
CBA/J MGP_CBAJ_G0022964
protein coding gene Chr17:24382696-24384697 (-)
DBA/2J MGP_DBA2J_G0023096
protein coding gene Chr17:21569375-21571375 (-)
FVB/NJ MGP_FVBNJ_G0023063
protein coding gene Chr17:21294027-21296029 (-)
LP/J MGP_LPJ_G0023170
protein coding gene Chr17:22848900-22850900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023082
protein coding gene Chr17:24145202-24147207 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023710
protein coding gene Chr17:22310695-22312695 (-)
PWK/PhJ MGP_PWKPhJ_G0022242
protein coding gene Chr17:20354429-20356428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022062
protein coding gene Chr17:20334557-20336569 (-)
WSB/EiJ MGP_WSBEiJ_G0022557
protein coding gene Chr17:22365883-22367884 (-)



Homology
more
  • Human Ortholog
    TNFRSF12A, TNF receptor superfamily member 12A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF12A, TNF receptor superfamily member 12A
  • Synonyms
    CD266, FN14, TWEAKR
  • Links
    NCBI Gene ID: 51330
    neXtProt AC: NX_Q9NP84
    UniProt: Q9NP84

  • Chr Location
    16p13.3; chr16:3018445-3022383 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced liver progenitor ("oval") cell proliferation in response to chemically-induced liver injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27279 NCBI Gene Model | MGI Sequence Detail 2005 C57BL/6J ±  kb
transcript NM_013749 RefSeq | MGI Sequence Detail 980 C57BL/6  
polypeptide Q9CR75 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146391, MGI:2147148
References
more
  • Summaries
    All 84
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 35
  • Earliest
    J:58335 Meighan-Mantha RL, et al., The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999 Nov 12;274(46):33166-76
  • Latest
    J:343504 Guerrero-Hue M, et al., Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury. Biomed Pharmacother. 2023 Dec 31;169:115925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory