Bcap31 MGI Mouse Gene Detail - MGI:1350933 - B cell receptor associated protein 31

Symbol

Bcap31
Name

B cell receptor associated protein 31
Synonyms

BAP31

Feature Type

protein coding gene
IDs

MGI:1350933
NCBI Gene: 27061
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:72729784-72759781 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.38 cM, cytoband A6
Mapping Data

2 experiments

SNPs within 2kb

174 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350933	protein coding gene	ChrX:72729784-72761421 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035816	protein coding gene	ChrX:69456123-69490650 (-)
A/J	MGP_AJ_G0035797	protein coding gene	ChrX:69655191-69687417 (-)
AKR/J	MGP_AKRJ_G0035722	protein coding gene	ChrX:71464099-71493831 (-)
BALB/cJ	MGP_BALBcJ_G0035782	protein coding gene	ChrX:68688388-68718342 (-)
C3H/HeJ	MGP_C3HHeJ_G0035487	protein coding gene	ChrX:69930184-69961140 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036312	protein coding gene	ChrX:71588793-71621070 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033156	protein coding gene	ChrX:68692756-68723488 (-)
CAST/EiJ	MGP_CASTEiJ_G0034778	protein coding gene	ChrX:55276367-55308230 (-)
CBA/J	MGP_CBAJ_G0035462	protein coding gene	ChrX:73546256-73576114 (-)
DBA/2J	MGP_DBA2J_G0035619	protein coding gene	ChrX:69117538-69147597 (-)
FVB/NJ	MGP_FVBNJ_G0035563	protein coding gene	ChrX:68446026-68476542 (-)
LP/J	MGP_LPJ_G0035704	protein coding gene	ChrX:70241973-70272075 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035601	protein coding gene	ChrX:76135880-76166653 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036334	protein coding gene	ChrX:69280518-69310797 (-)
PWK/PhJ	MGP_PWKPhJ_G0034477	protein coding gene	ChrX:53290351-53323123 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034311	protein coding gene	ChrX:56183812-56214539 (-)
WSB/EiJ	MGP_WSBEiJ_G0034919	protein coding gene	ChrX:68551642-68581558 (-)

Human Ortholog

BCAP31, B cell receptor associated protein 31

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCAP31, B cell receptor associated protein 31
Synonyms

6C6-AG, BAP31, CDM, DDCH, DELXQ28, DXS1357E, MICRODELXq28
Links

HGNC:16695

NCBI Gene ID: 10134

neXtProt AC: NX_P51572

UniProt: P51572
Chr Location

Xq28; chrX:153700492-153724565 (-) GRCh38

MGI Vertebrate Homology

Bcap31 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCAP31
Gene Tree

Bcap31

Diseases

2 with human BCAP31 associations

				Human Disease	Mouse Models
				deafness, dystonia, and cerebral hypomyelination IDs deafness, dystonia, and cerebral hypomyelination DOID:0112123 OMIM:300475 ORDO:369939
				sensorineural hearing loss IDs sensorineural hearing loss DOID:10003 DOID:11053 DOID:12112 DOID:12114 ICD10CM:H90.5 ICD9CM_2006:389.11 ICD9CM_2006:389.14 ICD9CM:389.1 ICD9CM:389.10 ICD9CM:389.14 MESH:D006319 NCI:C26739 UMLS_CUI:C0018784

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

3
Gene trapped

13
Targeted

2
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

48
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

164
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcap31

ZFIN bcap31

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All Sequences

44
RefSeq

10
UniProt

2
CCDS

CCDS30209.1

Ensembl

ENSMUSG00000002015 (Evidence)
NCBI Gene

27061

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002015	Ensembl Gene Model \| MGI Sequence Detail	29998	C57BL/6J	± kb
transcript	ENSMUST00000002091	Ensembl \| MGI Sequence Detail	1219	Not Applicable
polypeptide	ENSMUSP00000002091	Ensembl \| MGI Sequence Detail	245	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004675 B-cell receptor-associated protein 31

(term hierarchy)
InterPro Domains

IPR040463 BAP29/BAP31, transmembrane domain

IPR041672 Bap31/Bap29 cytoplasmic coiled-coil domain

IPR008417 B-cell receptor-associated protein 29/31

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All nucleic 164

cDNA 164

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 14
Earliest

J:19988 Kim KM, et al., Two new proteins preferentially associated with membrane immunoglobulin D. EMBO J. 1994 Aug 15;13(16):3793-800
Latest

J:340259 Wei X, et al., BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation. Int J Biol Sci. 2023;19(6):1713-1730

TSS for Bcap31:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163566	ChrX:72761456-72761470 (-)	-1,682 bp
Tssr163565	ChrX:72761436-72761448 (-)	-1,661 bp
Tssr163564	ChrX:72760048-72760072 (-)	-279 bp
Tssr163563	ChrX:72759804-72759815 (-)	-29 bp
Tssr163562	ChrX:72759751-72759793 (-)	9 bp
Tssr163561	ChrX:72756128-72756149 (-)	3,642 bp
Tssr163560	ChrX:72738850-72738853 (-)	20,929 bp
Tssr163559	ChrX:72733187-72733229 (-)	26,573 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23