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Ncoa4 Gene Detail
Summary
  • Symbol
    Ncoa4
  • Name
    nuclear receptor coactivator 4
  • Synonyms
    1110034E15Rik, 4432406M01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350932
    NCBI Gene: 27057
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31881884-31901210 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350932
 protein coding gene Chr14:31881822-31901812 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021139
 protein coding gene Chr14:25392831-25413029 (+)
A/J MGP_AJ_G0021087
 protein coding gene Chr14:24422969-24442960 (+)
AKR/J MGP_AKRJ_G0021064
 protein coding gene Chr14:25569574-25589561 (+)
BALB/cJ MGP_BALBcJ_G0021091
 protein coding gene Chr14:24598823-24620760 (+)
C3H/HeJ MGP_C3HHeJ_G0020874
 protein coding gene Chr14:25446065-25466050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021523
 protein coding gene Chr14:26402974-26429397 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019086
 protein coding gene Chr14:24488002-24508296 (+)
CAST/EiJ MGP_CASTEiJ_G0020399
 protein coding gene Chr14:25237030-25257003 (+)
CBA/J MGP_CBAJ_G0020841
 protein coding gene Chr14:27393099-27413162 (+)
DBA/2J MGP_DBA2J_G0020963
 protein coding gene Chr14:24455978-24475998 (+)
FVB/NJ MGP_FVBNJ_G0020947
 protein coding gene Chr14:24415665-24438127 (+)
LP/J MGP_LPJ_G0021032
 protein coding gene Chr14:25715350-25736154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020973
 protein coding gene Chr14:26631430-26651538 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021556
 protein coding gene Chr14:25343975-25363967 (+)
PWK/PhJ MGP_PWKPhJ_G0020147
 protein coding gene Chr14:23926488-23947232 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019971
 protein coding gene Chr14:24950538-24970437 (+)
WSB/EiJ MGP_WSBEiJ_G0020454
 protein coding gene Chr14:25405941-25425981 (+)



Homology
more
  • Human Ortholog
    NCOA4, nuclear receptor coactivator 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA4, nuclear receptor coactivator 4
  • Synonyms
    ARA70, ELE1, PTC3, RFG
  • Links
    NCBI Gene ID: 8031
    UniProt: Q13772

  • Chr Location
    10q11.22; chr10:46005088-46030623 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mouse embryonic fibroblasts isolated from homozygous null mice exhibit abnormal DNA replication, decreased fibroblast proliferation, and early cellular replicative senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    101
  • cDNA Data
    23
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27057 NCBI Gene Model | MGI Sequence Detail 19327 C57BL/6J ±  kb
transcript NM_001284319 RefSeq | MGI Sequence Detail 3484 C57BL/6  
polypeptide Q5U4H9 UniProt | EBI | MGI Sequence Detail 625 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1913942, MGI:1915907, MGI:2145605
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:341244 Jin L, et al., STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. Free Radic Biol Med. 2023 Aug 25;208:348-360
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory