Rpl8 MGI Mouse Gene Detail - MGI:1350927

Symbol

Rpl8
Name

ribosomal protein L8

Feature Type

protein coding gene
IDs

MGI:1350927
NCBI Gene: 26961
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:76788278-76790514 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.28 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

29 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350927	protein coding gene	Chr15:76788271-76790518 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022016	protein coding gene	Chr15:77022698-77024945 (+)
A/J	MGP_AJ_G0021974	protein coding gene	Chr15:74194402-74196649 (+)
AKR/J	MGP_AKRJ_G0021957	protein coding gene	Chr15:76214720-76217186 (+)
BALB/cJ	MGP_BALBcJ_G0021983	protein coding gene	Chr15:74217334-74219581 (+)
C3H/HeJ	MGP_C3HHeJ_G0021755	protein coding gene	Chr15:76255940-76258473 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022423	protein coding gene	Chr15:79894866-79897113 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019952	protein coding gene	Chr15:70845425-70847581 (+)
CAST/EiJ	MGP_CASTEiJ_G0021274	protein coding gene	Chr15:77055697-77057943 (+)
CBA/J	MGP_CBAJ_G0021722	protein coding gene	Chr15:82427344-82430785 (+)
DBA/2J	MGP_DBA2J_G0021847	protein coding gene	Chr15:73732531-73735632 (+)
FVB/NJ	MGP_FVBNJ_G0021827	protein coding gene	Chr15:72791786-72794033 (+)
LP/J	MGP_LPJ_G0021918	protein coding gene	Chr15:77101980-77104227 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021852	protein coding gene	Chr15:87750719-87752966 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022443	protein coding gene	Chr15:76478817-76481064 (+)
PWK/PhJ	MGP_PWKPhJ_G0021015	protein coding gene	Chr15:73902378-73904735 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020855	protein coding gene	Chr15:76189514-76192391 (+)
WSB/EiJ	MGP_WSBEiJ_G0021326	protein coding gene	Chr15:76582733-76585638 (+)

Human Ortholog

RPL8, ribosomal protein L8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPL8, ribosomal protein L8
Synonyms

L8, uL2
Links

HGNC:10368

NCBI Gene ID: 6132

neXtProt AC: NX_P62917

UniProt: P62917
Chr Location

8q24.3; chr8:144789765-144792587 (-) GRCh38

MGI Vertebrate Homology

Rpl8 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPL8
Protein SuperFamily

Ribosomal_L2
Gene Tree

Rpl8

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References

1 with disease annotations

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Phenotype Summary

28 phenotype references

All Mutations and Alleles

20
Chemically induced (other)

3
Endonuclease-mediated

1
Gene trapped

13
Radiation induced

2
Targeted

1
Genomic Mutations

5 involving Rpl8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

26
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

3
cDNA Data

886
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rpl8

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS27595.1

Ensembl

ENSMUSG00000003970 (Evidence)
NCBI Gene

26961

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003970	Ensembl Gene Model \| MGI Sequence Detail	2237	C57BL/6J	± kb
transcript	ENSMUST00000004072	Ensembl \| MGI Sequence Detail	851	Not Applicable
polypeptide	ENSMUSP00000004072	Ensembl \| MGI Sequence Detail	257	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014235 eukaryotic-type large ribosomal subunit protein uL2

(term hierarchy)
PDB

6SWA, 7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR002171 Large ribosomal subunit protein uL2

IPR023672 Large ribosomal subunit protein uL2, archaeal-type

IPR022671 Large ribosomal subunit protein uL2, conserved site

IPR022669 Large ribosomal subunit protein uL2, C-terminal

IPR014722 Large ribosomal subunit protein uL2, domain 2

IPR014726 Large ribosomal subunit protein uL2, domain 3

IPR022666 Large ribosomal subunit protein uL2, RNA-binding domain

IPR012340 Nucleic acid-binding, OB-fold

IPR008991 Translation protein SH3-like domain superfamily

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All nucleic 886

cDNA 886

Microarray probesets 3

Summaries

All 61

Developmental Gene Expression 5

Diseases 1

Gene Ontology 10

Phenotypes 28
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rpl8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131832	Chr15:76788270-76788292 (+)	3 bp
Tssr131833	Chr15:76788488-76788506 (+)	219 bp
Tssr131834	Chr15:76788542-76788561 (+)	274 bp
Tssr131835	Chr15:76788567-76788610 (+)	311 bp
Tssr131836	Chr15:76788735-76788773 (+)	476 bp
Tssr131837	Chr15:76788834-76788848 (+)	563 bp
Tssr131838	Chr15:76789060-76789071 (+)	788 bp
Tssr131839	Chr15:76789084-76789114 (+)	821 bp
Tssr131840	Chr15:76789126-76789136 (+)	853 bp
Tssr131841	Chr15:76789193-76789204 (+)	921 bp
Tssr131842	Chr15:76790066-76790080 (+)	1,795 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23