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Rpl8 Gene Detail
Summary
  • Symbol
    Rpl8
  • Name
    ribosomal protein L8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350927
    NCBI Gene: 26961
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76788278-76790514 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.28 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350927
protein coding gene Chr15:76788271-76790518 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022016
protein coding gene Chr15:77022698-77024945 (+)
A/J MGP_AJ_G0021974
protein coding gene Chr15:74194402-74196649 (+)
AKR/J MGP_AKRJ_G0021957
protein coding gene Chr15:76214720-76217186 (+)
BALB/cJ MGP_BALBcJ_G0021983
protein coding gene Chr15:74217334-74219581 (+)
C3H/HeJ MGP_C3HHeJ_G0021755
protein coding gene Chr15:76255940-76258473 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022423
protein coding gene Chr15:79894866-79897113 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019952
protein coding gene Chr15:70845425-70847581 (+)
CAST/EiJ MGP_CASTEiJ_G0021274
protein coding gene Chr15:77055697-77057943 (+)
CBA/J MGP_CBAJ_G0021722
protein coding gene Chr15:82427344-82430785 (+)
DBA/2J MGP_DBA2J_G0021847
protein coding gene Chr15:73732531-73735632 (+)
FVB/NJ MGP_FVBNJ_G0021827
protein coding gene Chr15:72791786-72794033 (+)
LP/J MGP_LPJ_G0021918
protein coding gene Chr15:77101980-77104227 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021852
protein coding gene Chr15:87750719-87752966 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022443
protein coding gene Chr15:76478817-76481064 (+)
PWK/PhJ MGP_PWKPhJ_G0021015
protein coding gene Chr15:73902378-73904735 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020855
protein coding gene Chr15:76189514-76192391 (+)
WSB/EiJ MGP_WSBEiJ_G0021326
protein coding gene Chr15:76582733-76585638 (+)



Homology
more
  • Human Ortholog
    RPL8, ribosomal protein L8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL8, ribosomal protein L8
  • Synonyms
    L8, uL2
  • Links
    NCBI Gene ID: 6132
    neXtProt AC: NX_P62917
    UniProt: P62917

  • Chr Location
    8q24.3; chr8:144789765-144792587 (-)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003970 Ensembl Gene Model | MGI Sequence Detail 2237 C57BL/6J ±  kb
transcript ENSMUST00000004072 Ensembl | MGI Sequence Detail 851 Not Applicable  
polypeptide ENSMUSP00000004072 Ensembl | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014235 eukaryotic-type large ribosomal subunit protein uL2
  • PDB
  • InterPro Domains
    IPR002171 Large ribosomal subunit protein uL2
    IPR023672 Large ribosomal subunit protein uL2, archaeal-type
    IPR022671 Large ribosomal subunit protein uL2, conserved site
    IPR022669 Large ribosomal subunit protein uL2, C-terminal
    IPR014722 Large ribosomal subunit protein uL2, domain 2
    IPR014726 Large ribosomal subunit protein uL2, domain 3
    IPR022666 Large ribosomal subunit protein uL2, RNA-binding domain
    IPR012340 Nucleic acid-binding, OB-fold
    IPR008991 Translation protein SH3-like domain superfamily
Molecular
Reagents
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  • All nucleic 886
    cDNA 886

    Microarray probesets 3
References
more
  • Summaries
    All 61
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 10
    Phenotypes 28
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory