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Dpysl2 Gene Detail
Summary
  • Symbol
    Dpysl2
  • Name
    dihydropyrimidinase-like 2
  • Synonyms
    Crmp2, DRP2, TOAD-64, Ulip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349763
    NCBI Gene: 12934
  • Alliance
    genome feature page
  • Transcription Start Sites
    46 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67040313-67148410 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3248 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349763
 protein coding gene Chr14:67040313-67148490 (-)
129S1/SvImJ ENSMUSG00200026568
 protein coding gene Chr14:55649044-55715360 (-)
A/J ENSMUSG00195013217
 protein coding gene Chr14:55820695-55887188 (-)
AKR/J ENSMUSG00220027144
 protein coding gene Chr14:55161377-55227877 (-)
BALB/cJ ENSMUSG00180032319
 protein coding gene Chr14:55436909-55503407 (-)
C3H/HeJ ENSMUSG00175035211
 protein coding gene Chr14:57185500-57251813 (-)
C57BL/6NJ ENSMUSG00215011339
 protein coding gene Chr14:55374868-55440981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019442
 protein coding gene Chr14:57951902-58018089 (-)
CAST/EiJ ENSTCUG00005037609
 protein coding gene Chr14:57077960-57144468 (-)
CBA/J ENSMUSG00210037259
 protein coding gene Chr14:55809491-55875979 (-)
DBA/2J ENSMUSG00185022915
 protein coding gene Chr14:60983335-61049656 (-)
FVB/NJ ENSMUSG00205026733
 protein coding gene Chr14:55323563-55390049 (-)
JF1/MsJ ENSUMUG00000041785
 protein coding gene Chr14:72149977-72216547 (-)
LP/J ENSMUSG00230035431
 protein coding gene Chr14:73012549-73078866 (-)
NOD/ShiLtJ ENSMUSG00190038054
 protein coding gene Chr14:55602701-55669188 (-)
NZO/HlLtJ ENSMUSG00225039369
 protein coding gene Chr14:63335572-63402065 (-)
PWK/PhJ ENSLUMG00010031632
 protein coding gene Chr14:55029661-55095875 (-)
SPRET/EiJ ENSMSPG00010029372
 protein coding gene Chr14:58545559-58612045 (-)
WSB/EiJ ENSIUOG00005037211
 protein coding gene Chr14:55040289-55106771 (-)



Homology
more
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Synonyms
    CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
  • Links
    NCBI Gene ID: 1808
    UniProt: Q16555

  • Chr Location
    8p21.2; chr8:26514031-26658178 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    171
  • cDNA Data
    7
  • Literature Summary
    19
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022048 Ensembl Gene Model | MGI Sequence Detail 108098 C57BL/6J ±  kb
transcript ENSMUST00000249932 Ensembl | MGI Sequence Detail 4681 Not Applicable  
polypeptide ENSMUSP00000160026 Ensembl | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006680 dihydropyrimidinase-related protein 2
    (term hierarchy)
  • PDB
    5UQC
  • InterPro Domains
    IPR006680 Amidohydrolase-related
    IPR011778 D-phenylhydantoinase/dihydropyrimidinase
    IPR032466 Metal-dependent hydrolase
    IPR011059 Metal-dependent hydrolase, composite domain superfamily
    IPR050378 Metallo-dependent Hydrolases Superfamily
  • GlyGen
    O08553 12 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (8 sites)
Molecular
Reagents
less
  • All nucleic 10
    cDNA 8
    Primer pair 2
    Antibodies 6

    Microarray probesets 4
Other
Accession IDs
less
MGI:1270853, MGI:2145700
References
more
  • Summaries
    All 120
    Developmental Gene Expression 19
    Gene Ontology 13
    Phenotypes 37
  • Earliest
    J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
  • Latest
    J:389436 Guevara VA, et al., Genetic suppressions of CRMP2 phosphorylation ameliorate alpha-synuclein accumulation in an square-synucleinopathy mouse model. Neurosci Lett. 2026 Jun 14;:138661
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory