Gprin1 MGI Mouse Gene Detail - MGI:1349455 - G protein-regulated inducer of neurite outgrowth 1

Symbol

Gprin1
Name

G protein-regulated inducer of neurite outgrowth 1
Synonyms

GRIN1, Z16

Feature Type

protein coding gene
IDs

MGI:1349455
NCBI Gene: 26913
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:54884484-54897486 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.18 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

381 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349455	protein coding gene	Chr13:54884484-54897687 (-)
129S1/SvImJ	ENSMUSG00200016120	protein coding gene	Chr13:51756911-51770115 (-)
A/J	ENSMUSG00195042393	protein coding gene	Chr13:51223721-51236944 (-)
AKR/J	ENSMUSG00220036329	protein coding gene	Chr13:50768352-50781597 (-)
BALB/cJ	ENSMUSG00180014923	protein coding gene	Chr13:51474993-51488223 (-)
C3H/HeJ	ENSMUSG00175034903	protein coding gene	Chr13:51261472-51274695 (-)
C57BL/6NJ	ENSMUSG00215035192	protein coding gene	Chr13:51285953-51299160 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018544	protein coding gene	Chr13:50159088-50172212 (-)
CAST/EiJ	ENSTCUG00005034722	protein coding gene	Chr13:51685169-51698142 (-)
CBA/J	ENSMUSG00210036148	protein coding gene	Chr13:51466292-51479517 (-)
DBA/2J	ENSMUSG00185016730	protein coding gene	Chr13:52308225-52321433 (-)
FVB/NJ	ENSMUSG00205041446	protein coding gene	Chr13:51115053-51128259 (-)
JF1/MsJ	ENSUMUG00000013692	protein coding gene	Chr13:51710156-51723122 (-)
LP/J	ENSMUSG00230031179	protein coding gene	Chr13:61652790-61665985 (-)
NOD/ShiLtJ	ENSMUSG00190027985	protein coding gene	Chr13:51355273-51368511 (-)
NZO/HlLtJ	ENSMUSG00225032792	protein coding gene	Chr13:55380012-55393216 (-)
PWK/PhJ	ENSLUMG00010020095	protein coding gene	Chr13:50577748-50590724 (-)
SPRET/EiJ	ENSMSPG00010032702	protein coding gene	Chr13:51002486-51007731 (-)
WSB/EiJ	ENSIUOG00005023483	protein coding gene	Chr13:50782300-50795498 (-)

Human Ortholog

GPRIN1, G protein regulated inducer of neurite outgrowth 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPRIN1, G protein regulated inducer of neurite outgrowth 1
Synonyms

GRIN1
Links

HGNC:24835

NCBI Gene ID: 114787

UniProt: Q7Z2K8
Chr Location

5q35.2; chr5:176595802-176610177 (-) GRCh38

MGI Vertebrate Homology

Gprin1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPRIN1
Gene Tree

Gprin1

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

2
Genomic Mutations

2 involving Gprin1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1017
Tissues

189
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gprin1

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS26534.1

Ensembl

ENSMUSG00000069227 (Evidence)
NCBI Gene

26913

			Length	Strain/Species	Flank
genomic	26913	NCBI Gene Model \| MGI Sequence Detail	13003	C57BL/6J	± kb
transcript	NM_012014	RefSeq \| MGI Sequence Detail	4147	C57BL/6
polypeptide	Q3UNH4	UniProt \| EBI \| MGI Sequence Detail	932	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008199 G protein-regulated inducer of neurite outgrowth 1

(term hierarchy)
InterPro Domains

IPR026646 G protein-regulated inducer of neurite outgrowth

IPR032745 G protein-regulated inducer of neurite outgrowth, C-terminal
GlyGen

Q3UNH4 11 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (9 sites)

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All nucleic 15

cDNA 15

Antibodies 1

Microarray probesets 7

Summaries

All 142

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:375914 Srikanth KD, et al., The synaptic ectokinase VLK triggers the EphB2-NMDAR interaction to drive injury-induced pain. Science. 2025 Nov 20;390(6775):eadp1007

TSS for Gprin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122641	Chr13:54897721-54897733 (-)	-241 bp
Tssr122640	Chr13:54897662-54897706 (-)	-198 bp
Tssr122639	Chr13:54897440-54897510 (-)	11 bp
Tssr122638	Chr13:54897426-54897438 (-)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24