Ctsj MGI Mouse Gene Detail - MGI:1349426

Symbol

Ctsj
Name

cathepsin J
Synonyms

Cat P, CATP, CatRLP, Ctsp, rat gene/Cathepsin L-related protein

Feature Type

protein coding gene
IDs

MGI:1349426
NCBI Gene: 26898
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:61147993-61153739 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 32.62 cM
Mapping Data

5 experiments

SNPs within 2kb

249 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349426	protein coding gene	Chr13:61147993-61153773 (-)
129S1/SvImJ	ENSMUSG00200016318	protein coding gene	Chr13:58085091-58090877 (-)
A/J	ENSMUSG00195043695	protein coding gene	Chr13:57538140-57543905 (-)
AKR/J	ENSMUSG00220035165	protein coding gene	Chr13:57052967-57058747 (-)
BALB/cJ	ENSMUSG00180014543	protein coding gene	Chr13:57761936-57767716 (-)
C3H/HeJ	ENSMUSG00175037117	protein coding gene	Chr13:57548044-57553825 (-)
C57BL/6NJ	ENSMUSG00215037302	protein coding gene	Chr13:57555756-57561536 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018623	protein coding gene	Chr13:56322797-56328399 (-)
CAST/EiJ	ENSTCUG00005038644	protein coding gene	Chr13:57950937-57956729 (-)
CBA/J	ENSMUSG00210035530	protein coding gene	Chr13:57752874-57758654 (-)
DBA/2J	ENSMUSG00185014366	protein coding gene	Chr13:58595960-58601740 (-)
FVB/NJ	ENSMUSG00205035013	protein coding gene	Chr13:57349075-57354851 (-)
JF1/MsJ	ENSUMUG00000012420	protein coding gene	Chr13:57938774-57944554 (-)
LP/J	ENSMUSG00230028679	protein coding gene	Chr13:67961736-67967500 (-)
NOD/ShiLtJ	ENSMUSG00190021121	protein coding gene	Chr13:57610150-57615931 (-)
NZO/HlLtJ	ENSMUSG00225046717	protein coding gene	Chr13:61652009-61657789 (-)
PWK/PhJ	ENSLUMG00010022266	protein coding gene	Chr13:56864097-56869883 (-)
SPRET/EiJ	ENSMSPG00010033941	protein coding gene	Chr13:57280033-57285820 (-)
WSB/EiJ	ENSIUOG00005024648	protein coding gene	Chr13:57084724-57090508 (-)

Human Ortholog

CTSL, cathepsin L

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTSL, cathepsin L
Synonyms

CATL, CTSL1, MEP
Links

HGNC:2537

NCBI Gene ID: 1514

UniProt: P07711
Chr Location

9q21.33; chr9:87724051-87731469 (+) GRCh38

MGI Vertebrate Homology

Ctsj stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: CTSL
Gene Tree

Ctsj

Diseases

1 with human CTSL associations

				Human Disease	Mouse Models
				hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Ctsj
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

667
Tissues

39
cDNA Data

87
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS49291.1, CCDS88467.1

Ensembl

ENSMUSG00000055298 (Evidence)
NCBI Gene

26898

			Length	Strain/Species	Flank
genomic	26898	NCBI Gene Model \| MGI Sequence Detail	5747	C57BL/6J	± kb
transcript	NM_001356291	RefSeq \| MGI Sequence Detail	1387	ZRU/MplStud
polypeptide	Q9R014	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006213 cathepsin J

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR013201 Cathepsin propeptide inhibitor domain (I29)

IPR025661 Cysteine peptidase, asparagine active site

IPR000169 Cysteine peptidase, cysteine active site

IPR025660 Cysteine peptidase, histidine active site

IPR039417 Papain-like cysteine endopeptidase

IPR038765 Papain-like cysteine peptidase superfamily

IPR013128 Peptidase C1A

IPR000668 Peptidase C1A, papain C-terminal
GlyGen

Q9R014 4 sites

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All nucleic 90

cDNA 88

Primer pair 2

Microarray probesets 3

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MGI:1349662

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctsj:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122937	Chr13:61153732-61153744 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24