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Cops7a Gene Detail
Summary
  • Symbol
    Cops7a
  • Name
    COP9 signalosome subunit 7A
  • Synonyms
    COP9 complex S7a, D6Ertd35e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349400
    NCBI Gene: 26894
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124935376-124942501 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    203 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349400
 protein coding gene Chr6:124935376-124974866 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031279
 protein coding gene Chr6:128277096-128284211 (-)
A/J MGP_AJ_G0031249
 protein coding gene Chr6:123446214-123453346 (-)
AKR/J MGP_AKRJ_G0031177
 protein coding gene Chr6:126818108-126825240 (-)
BALB/cJ MGP_BALBcJ_G0031257
 protein coding gene Chr6:123044849-123051981 (-)
C3H/HeJ MGP_C3HHeJ_G0030980
 protein coding gene Chr6:126874097-126881223 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031713
 protein coding gene Chr6:131663923-131671037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028863
 protein coding gene Chr6:120656111-120663206 (-)
CAST/EiJ MGP_CASTEiJ_G0030361
 protein coding gene Chr6:127080922-127088051 (-)
CBA/J MGP_CBAJ_G0030941
 protein coding gene Chr6:136699819-136706951 (-)
DBA/2J MGP_DBA2J_G0031097
 protein coding gene Chr6:122374833-122381966 (-)
FVB/NJ MGP_FVBNJ_G0031047
 protein coding gene Chr6:121278013-121285143 (-)
LP/J MGP_LPJ_G0031177
 protein coding gene Chr6:128450147-128457279 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031085
 protein coding gene Chr6:140743186-140750316 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031748
 protein coding gene Chr6:126709205-126716335 (-)
PWK/PhJ MGP_PWKPhJ_G0030076
 protein coding gene Chr6:120611093-120618298 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029905
 protein coding gene Chr6:124791833-124799073 (-)
WSB/EiJ MGP_WSBEiJ_G0030446
 protein coding gene Chr6:127079399-127086528 (-)



Homology
more
  • Human Ortholog
    COPS7A, COP9 signalosome subunit 7A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPS7A, COP9 signalosome subunit 7A
  • Synonyms
    CSN7, CSN7A, SGN7a
  • Links
    NCBI Gene ID: 50813
    neXtProt AC: NX_Q9UBW8
    UniProt: Q9UBW8

  • Chr Location
    12p13.31; chr12:6724014-6731875 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    39
  • cDNA Data
    150
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030127 Ensembl Gene Model | MGI Sequence Detail 7126 C57BL/6J ±  kb
    transcript ENSMUST00000112439 Ensembl | MGI Sequence Detail 1328 Not Applicable  
    polypeptide ENSMUSP00000108058 Ensembl | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005744 COP9 signalosome complex subunit 7a
      (term hierarchy)
    • InterPro Domains
      IPR041481 COP9 signalosome complex subunit 7, helix I
      IPR045237 Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7
      IPR000717 Proteasome component (PCI) domain
    • GlyGen
      Q9CZ04 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 150
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1098768
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory