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Foxj1 Gene Detail
Summary
  • Symbol
    Foxj1
  • Name
    forkhead box J1
  • Synonyms
    FKHL-13, Hfh4, HFH-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347474
    NCBI Gene: 15223
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116221530-116226225 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347474
 protein coding gene Chr11:116221530-116226331 (-)
129S1/SvImJ ENSMUSG00200050800
 protein coding gene Chr11:113588353-113593049 (-)
A/J ENSMUSG00195028490
 protein coding gene Chr11:113292403-113297101 (-)
AKR/J ENSMUSG00220023310
 protein coding gene Chr11:113397277-113401970 (-)
BALB/cJ ENSMUSG00180050565
 protein coding gene Chr11:113589066-113593761 (-)
C3H/HeJ ENSMUSG00175037422
 protein coding gene Chr11:113544168-113548864 (-)
C57BL/6NJ ENSMUSG00215043767
 protein coding gene Chr11:113081700-113086396 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017440
 protein coding gene Chr11:112184988-112189734 (-)
CAST/EiJ ENSTCUG00005028544
 protein coding gene Chr11:112947178-112951883 (-)
CBA/J ENSMUSG00210050459
 protein coding gene Chr11:113264155-113268851 (-)
DBA/2J ENSMUSG00185025760
 protein coding gene Chr11:113580559-113585255 (-)
FVB/NJ ENSMUSG00205043964
 protein coding gene Chr11:113386801-113391497 (-)
JF1/MsJ ENSUMUG00000052518
 protein coding gene Chr11:113848872-113853584 (-)
LP/J ENSMUSG00230050700
 protein coding gene Chr11:114637489-114642185 (-)
NOD/ShiLtJ ENSMUSG00190029731
 protein coding gene Chr11:113612162-113616859 (-)
NZO/HlLtJ ENSMUSG00225051312
 protein coding gene Chr11:116690307-116695003 (-)
PWK/PhJ ENSLUMG00010019983
 protein coding gene Chr11:113365247-113369965 (-)
SPRET/EiJ ENSMSPG00010036077
 protein coding gene Chr11:113885762-113890347 (-)
WSB/EiJ ENSIUOG00005040145
 protein coding gene Chr11:113353107-113357802 (-)



Homology
more
  • Human Ortholog
    FOXJ1, forkhead box J1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXJ1, forkhead box J1
  • Synonyms
    CILD43, FKHL13, HFH-4, HFH4
  • Links
    NCBI Gene ID: 2302
    UniProt: Q92949

  • Chr Location
    17q25.1; chr17:76136333-76141245 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Foxj1 mouse models; 1 with human FOXJ1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 7 alleles in 11 genetic backgrounds
    19 phenotypes from multigenic genotypes
    4 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for targeted mutations in this gene exhibit random determination of left-right asymmetry and defective ciliogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1353
  • Tissues
    361
  • cDNA Data
    20
  • Literature Summary
    181
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034227 Ensembl Gene Model | MGI Sequence Detail 4696 C57BL/6J ±  kb
    transcript ENSMUST00000036215 Ensembl | MGI Sequence Detail 2623 Not Applicable  
    polypeptide ENSMUSP00000038351 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 6
      cDNA 25
      Primer pair 20
      Other 5
      Antibodies 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16697, MGI:99901
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 181
      Diseases 4
      Gene Ontology 27
      Phenotypes 62
    • Earliest
      J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
    • Latest
      J:383292 Zhu X, et al., Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis. Neuron. 2026 Mar 30;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory