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Foxl1 Gene Detail
Summary
  • Symbol
    Foxl1
  • Name
    forkhead box L1
  • Synonyms
    fkh6, fkh-6, Fkh6, FREAC7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347469
    NCBI Gene: 14241
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121854679-121857383 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347469
protein coding gene Chr8:121854572-121857383 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034210
protein coding gene Chr8:124605295-124607999 (+)
A/J MGP_AJ_G0034190
protein coding gene Chr8:119425433-119428137 (+)
AKR/J MGP_AKRJ_G0034117
protein coding gene Chr8:122909522-122912226 (+)
BALB/cJ MGP_BALBcJ_G0034184
protein coding gene Chr8:119642686-119645400 (+)
C3H/HeJ MGP_C3HHeJ_G0033895
protein coding gene Chr8:123640855-123643791 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034704
protein coding gene Chr8:128745792-128748496 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031646
protein coding gene Chr8:112294081-112296813 (+)
CAST/EiJ MGP_CASTEiJ_G0033222
protein coding gene Chr8:123657377-123660077 (+)
CBA/J MGP_CBAJ_G0033868
protein coding gene Chr8:133474962-133477753 (+)
DBA/2J MGP_DBA2J_G0034024
protein coding gene Chr8:118634677-118637419 (+)
FVB/NJ MGP_FVBNJ_G0033967
protein coding gene Chr8:117723330-117726478 (+)
LP/J MGP_LPJ_G0034113
protein coding gene Chr8:124731355-124734087 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034014
protein coding gene Chr8:135781710-135784428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034722
protein coding gene Chr8:123092812-123095515 (+)
PWK/PhJ MGP_PWKPhJ_G0032924
protein coding gene Chr8:118435646-118438351 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032764
protein coding gene Chr8:121802874-121805570 (+)
WSB/EiJ MGP_WSBEiJ_G0033338
protein coding gene Chr8:123842478-123845174 (+)



Homology
more
  • Human Ortholog
    FOXL1, forkhead box L1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXL1, forkhead box L1
  • Synonyms
    FKH6, FKHL11, FREAC7, OTSC11
  • Links
    NCBI Gene ID: 2300
    neXtProt AC: NX_Q12952
    UniProt: Q12952

  • Chr Location
    16q24.1; chr16:86576368-86583478 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human FOXL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit impaired stomach and intestine development, including impaired parietal cell differentiation, abnormal intestinal epithelium and crypt structure, gastric mucosal hyperplasia, growth retardation, and sometimes postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000097084 Ensembl Gene Model | MGI Sequence Detail 2705 C57BL/6J ±  kb
    transcript ENSMUST00000181609 Ensembl | MGI Sequence Detail 2705 Not Applicable  
    polypeptide ENSMUSP00000137732 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 10
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9818, MGI:95549
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 24
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:14165 Kaestner KH, et al., Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7628-31
    • Latest
      J:334878 Kraiczy J, et al., Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 Apr 6;30(4):433-449.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/14/2024
    MGI 6.23
    The Jackson Laboratory