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Atp2b3 Gene Detail
Summary
  • Symbol
    Atp2b3
  • Name
    ATPase, Ca++ transporting, plasma membrane 3
  • Synonyms
    6430519O13Rik, Pmca3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347353
    NCBI Gene: 320707
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72546692-72614611 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1040 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347353
 protein coding gene ChrX:72546356-72632267 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035812
 protein coding gene ChrX:69255782-69328281 (+)
A/J MGP_AJ_G0035793
 protein coding gene ChrX:69469993-69537553 (+)
AKR/J MGP_AKRJ_G0035718
 protein coding gene ChrX:71277526-71344941 (+)
BALB/cJ MGP_BALBcJ_G0035778
 protein coding gene ChrX:68501726-68570242 (+)
C3H/HeJ MGP_C3HHeJ_G0035483
 protein coding gene ChrX:69738191-69807030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036308
 protein coding gene ChrX:71391444-71465583 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033152
 protein coding gene ChrX:68508854-68576547 (+)
CAST/EiJ MGP_CASTEiJ_G0034774
 protein coding gene ChrX:55083190-55153140 (+)
CBA/J MGP_CBAJ_G0035458
 protein coding gene ChrX:73336835-73415126 (+)
DBA/2J MGP_DBA2J_G0035615
 protein coding gene ChrX:68933859-69001520 (+)
FVB/NJ MGP_FVBNJ_G0035559
 protein coding gene ChrX:68260495-68328953 (+)
LP/J MGP_LPJ_G0035700
 protein coding gene ChrX:70055251-70123201 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035597
 protein coding gene ChrX:75931128-76001146 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036330
 protein coding gene ChrX:69090426-69158043 (+)
PWK/PhJ MGP_PWKPhJ_G0034473
 protein coding gene ChrX:53103206-53172796 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034307
 protein coding gene ChrX:56000282-56069203 (+)
WSB/EiJ MGP_WSBEiJ_G0034915
 protein coding gene ChrX:68361272-68430162 (+)



Homology
more
  • Human Ortholog
    ATP2B3, ATPase plasma membrane Ca2+ transporting 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP2B3, ATPase plasma membrane Ca2+ transporting 3
  • Synonyms
    CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1
  • Links
    NCBI Gene ID: 492
    UniProt: Q16720

  • Chr Location
    Xq28; chrX:153517637-153582939 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATP2B3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    111
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031376 Ensembl Gene Model | MGI Sequence Detail 67920 C57BL/6J ±  kb
    transcript ENSMUST00000088429 Ensembl | MGI Sequence Detail 4483 Not Applicable  
    polypeptide ENSMUSP00000085775 Ensembl | MGI Sequence Detail 1220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
      7.2.2.10
    • InterPro Domains
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal
      IPR001757 P-type ATPase
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR044492 P-type ATPase, haloacid dehalogenase domain
      IPR018303 P-type ATPase, phosphorylation site
      IPR006408 P-type ATPase, subfamily IIB
      IPR023298 P-type ATPase, transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444577
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 8
      Phenotypes 8
    • Earliest
      J:57237 Zacharias DA, et al., Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse. Biochim Biophys Acta. 1999 Aug 5;1428(2-3):397-405
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/09/2026
    MGI 6.24     		The Jackson Laboratory