Usp5 MGI Mouse Gene Detail - MGI:1347343 - ubiquitin specific peptidase 5 (isopeptidase T)

Symbol

Usp5
Name

ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms

Ucht

Feature Type

protein coding gene
IDs

MGI:1347343
NCBI Gene: 22225
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:124791982-124806447 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

2 experiments

SNPs within 2kb

38 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347343	protein coding gene	Chr6:124791982-124806447 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031270	protein coding gene	Chr6:128121806-128136271 (-)
A/J	MGP_AJ_G0031240	protein coding gene	Chr6:123301296-123315761 (-)
AKR/J	MGP_AKRJ_G0031168	protein coding gene	Chr6:126666482-126680947 (-)
BALB/cJ	MGP_BALBcJ_G0031248	protein coding gene	Chr6:122900970-122915435 (-)
C3H/HeJ	MGP_C3HHeJ_G0030971	protein coding gene	Chr6:126713623-126728088 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031704	protein coding gene	Chr6:131505396-131519861 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028854	protein coding gene	Chr6:120511315-120525979 (-)
CAST/EiJ	MGP_CASTEiJ_G0030352	protein coding gene	Chr6:126917416-126931848 (-)
CBA/J	MGP_CBAJ_G0030932	protein coding gene	Chr6:136536932-136551397 (-)
DBA/2J	MGP_DBA2J_G0031088	protein coding gene	Chr6:122227828-122242293 (-)
FVB/NJ	MGP_FVBNJ_G0031038	protein coding gene	Chr6:121130137-121144602 (-)
LP/J	MGP_LPJ_G0031168	protein coding gene	Chr6:128292595-128307060 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031076	protein coding gene	Chr6:140596107-140610572 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031739	protein coding gene	Chr6:126559377-126573842 (-)
PWK/PhJ	MGP_PWKPhJ_G0030067	protein coding gene	Chr6:120458741-120473113 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029896	protein coding gene	Chr6:124640013-124657080 (-)
WSB/EiJ	MGP_WSBEiJ_G0030437	protein coding gene	Chr6:126918344-126932819 (-)

Human Ortholog

USP5, ubiquitin specific peptidase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP5, ubiquitin specific peptidase 5
Synonyms

ISOT
Links

HGNC:12628

NCBI Gene ID: 8078

neXtProt AC: NX_P45974

UniProt: P45974
Chr Location

12p13.31; chr12:6852118-6866632 (+) GRCh38.p7

Alliance of Genome Resources

Usp5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP5
Protein SuperFamily

UBP
Gene Tree

Usp5

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

2
Gene trapped

11
Targeted

3
Transgenic

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

209

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp5

ZFIN usp5

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Usp5 interacts with 102 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

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All Sequences

94
RefSeq

20
UniProt

4
CCDS

CCDS20531.1, CCDS85157.1

Ensembl

ENSMUSG00000038429 (Evidence)
NCBI Gene

22225

			Length	Strain/Species	Flank
genomic	22225	NCBI Gene Model \| MGI Sequence Detail	14466	C57BL/6J	± kb
transcript	NM_001410491	RefSeq \| MGI Sequence Detail	3216	C57BL/6
polypeptide	P56399	UniProt \| EBI \| MGI Sequence Detail	858	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017189 ubiquitin carboxyl-terminal hydrolase 5

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR041812 Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

IPR016652 Ubiquitinyl hydrolase

IPR041432 Ubiquitinyl hydrolase, variant UBP zinc finger

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001607 Zinc finger, UBP-type

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All nucleic 212

Genomic 3

cDNA 209

Microarray probesets 2

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MGI:1315191, MGI:2141357

Summaries

All 42

Diseases 1

Gene Ontology 6

Phenotypes 14
Earliest

J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
Latest

J:332255 Li J, et al., USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity. Nat Commun. 2022 Dec 17;13(1):7799

TSS for Usp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63182	Chr6:124806430-124806441 (-)	11 bp
Tssr63181	Chr6:124806361-124806415 (-)	59 bp
Tssr63180	Chr6:124805276-124805306 (-)	1,156 bp
Tssr63179	Chr6:124796399-124796416 (-)	10,039 bp
Tssr63178	Chr6:124795002-124795017 (-)	11,437 bp
Tssr63177	Chr6:124794974-124794984 (-)	11,468 bp
Tssr2011	Chr6:124794960-124794970 (-)	11,482 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/31/2023 MGI 6.22