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Usp5 Gene Detail
Summary
  • Symbol
    Usp5
  • Name
    ubiquitin specific peptidase 5 (isopeptidase T)
  • Synonyms
    Ucht
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347343
    NCBI Gene: 22225
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124791982-124806404 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347343
 protein coding gene Chr6:124791982-124806447 (-)
129S1/SvImJ ENSMUSG00200049620
 protein coding gene Chr6:121853332-121867795 (-)
A/J ENSMUSG00195046190
 protein coding gene Chr6:121306472-121320937 (-)
AKR/J ENSMUSG00220021894
 protein coding gene Chr6:120168034-120182499 (-)
BALB/cJ ENSMUSG00180048131
 protein coding gene Chr6:121645098-121659563 (-)
C3H/HeJ ENSMUSG00175040363
 protein coding gene Chr6:121306526-121320991 (-)
C57BL/6NJ ENSMUSG00215044282
 protein coding gene Chr6:121617071-121631536 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028854
 protein coding gene Chr6:120511315-120525979 (-)
CAST/EiJ ENSTCUG00005049431
 protein coding gene Chr6:121490131-121504563 (-)
CBA/J ENSMUSG00210038428
 protein coding gene Chr6:121345555-121360020 (-)
DBA/2J ENSMUSG00185038633
 protein coding gene Chr6:122045176-122059641 (-)
FVB/NJ ENSMUSG00205040606
 protein coding gene Chr6:120759898-120774363 (-)
JF1/MsJ ENSUMUG00000022025
 protein coding gene Chr6:120454506-120468985 (-)
LP/J ENSMUSG00230040811
 protein coding gene Chr6:123242057-123256522 (-)
NOD/ShiLtJ ENSMUSG00190050003
 protein coding gene Chr6:121016758-121031221 (-)
NZO/HlLtJ ENSMUSG00225015751
 protein coding gene Chr6:125264940-125279405 (-)
PWK/PhJ ENSLUMG00010039030
 protein coding gene Chr6:119721472-119735860 (-)
SPRET/EiJ ENSMSPG00010039487
 protein coding gene Chr6:122572852-122587425 (-)
WSB/EiJ ENSIUOG00005036603
 protein coding gene Chr6:121730185-121744660 (-)



Homology
more
  • Human Ortholog
    USP5, ubiquitin specific peptidase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP5, ubiquitin specific peptidase 5
  • Synonyms
    ISOT
  • Links
    NCBI Gene ID: 8078
    UniProt: P45974

  • Chr Location
    12p13.31; chr12:6852122-6866632 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    209
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22225 NCBI Gene Model | MGI Sequence Detail 14423 C57BL/6J ±  kb
transcript NM_001410491 RefSeq | MGI Sequence Detail 3216 ZRU/MplStud  
polypeptide P56399 UniProt | EBI | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017189 ubiquitin carboxyl-terminal hydrolase 5
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR009060 UBA-like superfamily
    IPR015940 Ubiquitin-associated domain
    IPR050185 Ubiquitin carboxyl-terminal hydrolase
    IPR041812 Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease USP, catalytic domain
    IPR016652 Ubiquitinyl hydrolase
    IPR041432 Ubiquitinyl hydrolase, variant UBP zinc finger
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001607 Zinc finger, UBP-type
  • GlyGen
    P56399 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 212
    Genomic 3
    cDNA 209

    Microarray probesets 2
Other
Accession IDs
less
MGI:1315191, MGI:2141357
References
more
  • Summaries
    All 59
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
  • Latest
    J:361258 Eibach Y, et al., The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes. Sci Adv. 2025 Jan 24;11(4):eado3852
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory