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Poli Gene Detail
Summary
  • Symbol
    Poli
  • Name
    polymerase (DNA directed), iota
  • Synonyms
    Rad30b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347081
    NCBI Gene: 26447
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr18:70641751-70663691 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 44.48 cM, cytoband E2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    709 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347081
 protein coding gene Chr18:70641751-70668021 (-)
129S1/SvImJ ENSMUSG00200023405
 protein coding gene Chr18:67871530-67893480 (-)
A/J ENSMUSG00195029888
 protein coding gene Chr18:67903841-67925782 (-)
AKR/J ENSMUSG00220022056
 protein coding gene Chr18:67855739-67877668 (-)
BALB/cJ ENSMUSG00180011337
 protein coding gene Chr18:68488871-68504609 (-)
C3H/HeJ ENSMUSG00175009841
 protein coding gene Chr18:68063798-68085727 (-)
C57BL/6NJ ENSMUSG00215009008
 protein coding gene Chr18:67402883-67424823 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022388
 protein coding gene Chr18:67162768-67178648 (-)
CAST/EiJ ENSTCUG00005015437
 protein coding gene Chr18:67049727-67065473 (-)
CBA/J ENSMUSG00210027061
 protein coding gene Chr18:68021941-68043869 (-)
DBA/2J ENSMUSG00185028101
 protein coding gene Chr18:67927915-67949843 (-)
FVB/NJ ENSMUSG00205009680
 protein coding gene Chr18:67377636-67399577 (-)
JF1/MsJ ENSUMUG00000017891
 protein coding gene Chr18:67865358-67881099 (-)
LP/J ENSMUSG00230038248
 protein coding gene Chr18:70000118-70022067 (-)
NOD/ShiLtJ ENSMUSG00190007799
 protein coding gene Chr18:67648922-67670862 (-)
NZO/HlLtJ ENSMUSG00225029921
 protein coding gene Chr18:69856641-69878580 (-)
PWK/PhJ ENSLUMG00010024339
 protein coding gene Chr18:68255831-68271556 (-)
SPRET/EiJ ENSMSPG00010036229
 protein coding gene Chr18:68446372-68465217 (-)
WSB/EiJ ENSIUOG00005005771
 protein coding gene Chr18:67479270-67501243 (-)



Homology
more
  • Human Ortholog
    POLI, DNA polymerase iota
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLI, DNA polymerase iota
  • Synonyms
    eta2, RAD30B, RAD3OB
  • Links
    NCBI Gene ID: 11201
    UniProt: Q9UNA4

  • Chr Location
    18q21.2; chr18:54269479-54321266 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation show normal somatic hypermutation of immunoglobulin variable genes and no significant increase in UV-induced epithelial skin tumor formation relative to controls; in contrast, formation of mesenchymal tumors by chronic UV irradiation is enhanced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    5
  • cDNA Data
    34
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038425 Ensembl Gene Model | MGI Sequence Detail 21941 C57BL/6J ±  kb
    transcript ENSMUST00000121674 Ensembl | MGI Sequence Detail 2778 Not Applicable  
    polypeptide ENSMUSP00000112563 Ensembl | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 34

      Microarray probesets 3
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:57245 McDonald JP, et al., Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. Genomics. 1999 Aug 15;60(1):20-30
    • Latest
      J:361605 Cao R, et al., Genes related to neural tube defects and glioblastoma. Sci Rep. 2025 Jan 30;15(1):3777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory